6c2f 上海市肿瘤研究所
  • 我所召开2020年全面从严治党暨党建工作大会
  • 癌基因与相关基因国家重点实验室学术委员会2020年度工作会议顺利召开
  • 上海市肿瘤研究所搬迁揭幕仪式于仁济医院新科研楼举办
  • 覃文新团队与René Bernards实验室合作发表肝癌精准治疗新策略论文
  • 上海市科学技术奖、上海医学科技奖揭晓,我所李宗海、张志刚团队喜获殊荣


  1. Yu, T., Y. Zhao, Z. Hu, J. Li, D. Chu, J. Zhang, Z. Li, B. Chen, X. Zhang, H. Pan, S. Li, H. Lin, L. Liu, M. Yan, X. He, and M. Yao, MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway. Cancer Res, 2017. 77(21): p. 5782-5794.
  2. Song, Y., Y. Gan, Q. Wang, Z. Meng, G. Li, Y. Shen, Y. Wu, P. Li, M. Yao, J. Gu, and H. Tu, Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve-Dependent Regulation of NKG2D and CCR5. Cancer Res, 2017. 77(7): p. 1611-1622.
  3. Ke, S., S. Chen, Z. Dong, C.S. Hong, Q. Zhang, L. Tang, P. Yang, J. Zhai, H. Yan, F. Shen, Z. Zhuang, W. Wen, and H. Wang, Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology, 2017. 65(1): p. 134-151.
  4. Jin, H., C. Wang, G. Jin, H. Ruan, D. Gu, L. Wei, H. Wang, N. Wang, E. Arunachalam, Y. Zhang, X. Deng, C. Yang, Y. Xiong, H. Feng, M. Yao, J. Fang, J. Gu, W. Cong, and W. Qin, Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1. Gastroenterology, 2017. 153(3): p. 799-811 e33.
  5. Jiang, S.H., J. Li, F.Y. Dong, J.Y. Yang, D.J. Liu, X.M. Yang, Y.H. Wang, M.W. Yang, X.L. Fu, X.X. Zhang, Q. Li, X.F. Pang, Y.M. Huo, J.F. Zhang, H.Y. Lee, S.J. Lee, W.X. Qin, J.R. Gu, Y.W. Sun, and Z.G. Zhang, Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice. Gastroenterology, 2017. 153(1): p. 277-291 e19.
  6. Zhang, L., C. Ge, F. Zhao, Y. Zhang, X. Wang, M. Yao, and J. Li, NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling. Cancer Res, 2016. 76(23): p. 7059-7071.
  7. Chen, J., P. Gao, S. Yuan, R. Li, A. Ni, L. Chu, L. Ding, Y. Sun, X.Y. Liu, and Y. Duan, Oncolytic Adenovirus Complexes Coated with Lipids and Calcium Phosphate for Cancer Gene Therapy. ACS Nano, 2016. 10(12): p. 11548-11560.
  8. Wang, B., A. Ma, L. Zhang, W.L. Jin, Y. Qian, G. Xu, B. Qiu, Z. Yang, Y. Liu, and Q. Xia, POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Nat Commun, 2015. 6: p. 8704.
  9. Qiu, Z., W. Guo, Q. Wang, Z. Chen, S. Huang, F. Zhao, M. Yao, Y. Zhao, and X. He, MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells. Gastroenterology, 2015. 149(6): p. 1587-1598 e11.
  10. Nie, H., J. Li, X.M. Yang, Q.Z. Cao, M.X. Feng, F. Xue, L. Wei, W. Qin, J. Gu, Q. Xia, and Z.G. Zhang, Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR-338-3p-PKLR axis in hepatocellular carcinoma. Hepatology, 2015. 62(4): p. 1145-59.
  11. Guo, W., Z. Qiu, Z. Wang, Q. Wang, N. Tan, T. Chen, Z. Chen, S. Huang, J. Gu, J. Li, M. Yao, Y. Zhao, and X. He, MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology, 2015. 62(4): p. 1132-44.
  12. Zhang, L., Z. Yang, A. Ma, Y. Qu, S. Xia, D. Xu, C. Ge, B. Qiu, Q. Xia, J. Li, and Y. Liu, Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma. Hepatology, 2014. 59(1): p. 178-89.
  13. Tian, H., C. Ge, H. Li, F. Zhao, H. Hou, T. Chen, G. Jiang, H. Xie, Y. Cui, M. Yao, and J. Li, Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma. Hepatology, 2014. 59(4): p. 1459-70.
  14. Li, J., X.M. Yang, Y.H. Wang, M.X. Feng, X.J. Liu, Y.L. Zhang, S. Huang, Z. Wu, F. Xue, W.X. Qin, J.R. Gu, Q. Xia, and Z.G. Zhang, Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling. J Hepatol, 2014. 60(6): p. 1225-34.
  15. Jia, D., Y. Jing, Z. Zhang, L. Liu, J. Ding, F. Zhao, C. Ge, Q. Wang, T. Chen, M. Yao, J. Li, J. Gu, and X. He, Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma. Cell Res, 2014. 24(2): p. 204-17.
  16. Jia, D., R. Dong, Y. Jing, D. Xu, Q. Wang, L. Chen, Q. Li, Y. Huang, Y. Zhang, Z. Zhang, L. Liu, S. Zheng, Q. Xia, H. Wang, K. Dong, and X. He, Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex. Hepatology, 2014. 60(5): p. 1686-96.
  17. Zhou, M., H. Wang, K. Zhou, X. Luo, X. Pan, B. Shi, H. Jiang, J. Zhang, K. Li, H.M. Wang, H. Gao, S. Lu, M. Yao, Y. Mao, H.Y. Wang, S. Yang, J. Gu, C. Li, and Z. Li, A novel EGFR isoform confers increased invasiveness to cancer cells. Cancer Res, 2013. 73(23): p. 7056-67.
  18. Wu, Q.J., Y. Yang, E. Vogtmann, J. Wang, L.H. Han, H.L. Li, and Y.B. Xiang, Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies. Ann Oncol, 2013. 24(4): p. 1079-87.
  19. Ding, J., S. Huang, Y. Wang, Q. Tian, R. Zha, H. Shi, Q. Wang, C. Ge, T. Chen, Y. Zhao, L. Liang, J. Li, and X. He, Genome-wide screening reveals that miR-195 targets the TNF-alpha/NF-kappaB pathway by down-regulating IkappaB kinase alpha and TAB3 in hepatocellular carcinoma. Hepatology, 2013. 58(2): p. 654-66.
  20. Zhang, W., X.O. Shu, H. Li, G. Yang, H. Cai, B.T. Ji, J. Gao, Y.T. Gao, W. Zheng, and Y.B. Xiang, Vitamin intake and liver cancer risk: a report from two cohort studies in China. J Natl Cancer Inst, 2012. 104(15): p. 1173-81.
  21. Zhang, L., H. Sun, F. Zhao, P. Lu, C. Ge, H. Li, H. Hou, M. Yan, T. Chen, G. Jiang, H. Xie, Y. Cui, X. Huang, J. Fan, M. Yao, and J. Li, BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma. Cancer Res, 2012. 72(16): p. 4276-85.
  22. Yang, W.S., M.Y. Wong, E. Vogtmann, R.Q. Tang, L. Xie, Y.S. Yang, Q.J. Wu, W. Zhang, and Y.B. Xiang, Meat consumption and risk of lung cancer: evidence from observational studies. Ann Oncol, 2012. 23(12): p. 3163-70.
  23. Li, H., C. Ge, F. Zhao, M. Yan, C. Hu, D. Jia, H. Tian, M. Zhu, T. Chen, G. Jiang, H. Xie, Y. Cui, J. Gu, H. Tu, X. He, M. Yao, Y. Liu, and J. Li, Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin beta1 signaling in human hepatocellular carcinoma. Hepatology, 2011. 54(3): p. 910-9.


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