材料学博士，研究方向为肿瘤靶向药物（基因）载体设计以及抗肿瘤给药系统的构建。作为课题负责人承担有国家自然科学基金面上项目3项，青年项目1项；上海市自然科学基金项目2项。作为科研骨干参与国家自然科学基金项目3项、上海市科委纳米科技研究项目2项。曾获上海市科学技术三等奖。参与发表SCI论文70余篇，在ACS Nano、Biomaterials等期刊以第一作者、通讯作者发表文章四十余篇。获得授权国家发明专利五项。

1. 克服顺铂耐药相关递送系统的构建

2. 新型药物/基因递送系统的设计及应用

3. 多模态分子影像探针用于疾病诊治研究

代表性论文

1. Yi Duan, Mengqiong Deng, Bin Liu, Xianwei Meng, Jinghan Liao, Yijie Qiu, Zhihua Wu, Jiangtao Lin, Yi Dong*, Yourong Duan*, Ying Sun*. Mitochondria targeted drug delivery system overcoming drug resistance in intrahepatic cholangiocarcinoma by reprogramming lipid metabolism. Biomaterials. 2024, 309.

2. Quan Wang, Yi Duan, Hongshu Jing, Zhihua Wu, Yu Tian, Ke Gong, Qianqian Guo, Jiali Zhang, Ying Sun, Zhaojun Li, Yourong Duan. Inhibition of atherosclerosis progression by modular micelles. Journal of Controlled Release. 2023, 354: 294-304.

3. Zhihua Wu, De Zhao, Xin Han, Jichang Liu, Ying Sun*, Yaogang Li*, Yourong Duan*. Deposition of hydrophilic Ti3C2Tx on a superhydrophobic ZnO nanorod array for improved surface-enhanced raman scattering performance. Journal of Nanobiotechnology. 2023, 21(1): 17.

4. Xupeng Yang, Meng Zhao, Zhihua Wu, Chuanrong Chen, Yanhua Zhang, Liting Wang, Qianqian Guo, Quan Wang, Shunshun Liang, Suxian Hu, Yourong Duan*, Ying Sun*. Nano-ultrasonic Contrast Agent for Chemoimmunotherapy of Breast Cancer by Immune Metabolism Reprogramming and Tumor Autophagy. ACS Nano. 2022, 16: 3417-3431.

5. Yanhua Zhang, Yang Dong, Hao Fu, Hui Huang, Zhihua Wu, Meng Zhao, Xupeng Yang, Qianqian Guo, Yourong Duan*, Ying Sun*. Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance. Biomaterials. 2021, 120478.

6. Meng Zhao#, Xupeng Yang#, Hao Fu, Chuanrong Chen, Yanghua Zhang, Zhihua Wu, Yourong Duan*, Ying Sun*. Immune/Hypoxic Tumor Microenvironment Regulation-Enhanced Photodynamic Treatment Realized by pH-Responsive Phase Transition-Targeting Nanobubbles, ACS Applied Materials & Interfaces, 2021, 13: 32763-32779.

7. Hui Huang, Yang Dong, Yanhua Zhang, Dan Ru, Zhihua Wu, Jiali Zhang, Ming Shen, Yourong Duan*, Ying Sun*. GSH-sensitive Pt(IV) prodrug-loaded phase-transitional nanoparticles with a hybrid lipid-polymer shell for precise theranostics against ovarian cancer. Theranostics. 2019, 9(4): 1047-1065.

8. Jie Xu#, Ying Sun#, Zeting Yuan#, Yijie Bao, Rongxin Li, Cheng Liu, YanYan Qiu, Ke Xu, Xiaojing Shi, Hui Yu, Teng Chen*, Yourong Duan*, Peihao Yin*. Bufalin-Loaded CaP/DPPE-PEG-EGF Nanospheres: Preparation, Cellular Uptake, Distribution, and Anti-Tumor Effects. Journal of Biomedical Nanotechnology. 2019, 15: 329–339.

9. Ying Sun#, Qi Wang#, Jianhua Chen, Lei Liu, Li Ding, Ming Shen, Jin Li, Baoshan Han, Yourong Duan. Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy. Theranostics. 2017, 7(18): 4424-4444.

 10.Jianhua Chen, Pei Gao, Sujing Yuan, Rongxin Li, Aimin Ni, Liang Chu, Li Ding, Ying Sun*, Xinyuan Liu*, Yourong Duan*. Oncolytic Adenovirus Complexes Coated with Lipids and Calcium Phosphate for Cancer Gene Therapy. ACS Nano. 2016, 10: 11548-11560.

1. 国家自然科学基金面上项目，82272829, 超声触发递送系统瘤内催化克服肝内胆管癌耐药与转移

2. 国家自然科学基金面上项目，81771839，电荷反转型共载Pt(IV)/siRNA纳米超声-磁共振双模态造影剂用于可视化治疗卵巢癌耐药的研究

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5. 上海市自然科学基金面上项目，22ZR1459700, 超声介导序贯响应纳米泡造影剂用于三阴性乳腺癌成像及免疫/光动力联合治疗的作用研究

6. 上海市自然科学基金面上项目，13ZR1440200，肿瘤微环境响应型载Pt前药纳米载体的构建及对卵巢癌的治疗研究

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4. 肿瘤细胞及肿瘤血管双靶向纳米粒、构建方法及应用. 中国，ZL 201510503842.3

5. 一种靶向超声相变型双模态显像纳米造影剂及其制备方法和应用. 中国，ZL201910823737.6

工作人员

武志华 博士 助理研究员

武晓丹 博士 助理研究员

研究生

邓梦琼 硕士研究生

朱    晏 硕士研究生

罗博之 硕士研究生

陆思雯 硕士研究生