张艳丽，博士，副研究员，硕士生导师。2012年博士毕业于复旦大学上海医学院，生物化学与分子生物学专业。2021年至2023年在剑桥大学，访问学者。近年来，主要致力于消化道肿瘤尤其是肝癌和胰腺癌微环境方面的研究。作为负责人，主持国家自然科学基金面上和青年项目、上海市自然科学基金面上项目、上海市卫生健康委员会临床研究专项等。

1. 肿瘤微环境（TME），肿瘤-间质的相互作用，尤其是细胞外基质蛋白与膜受体之间的信号转导；

2. 液-液相分离（LLPS），及其对肿瘤发生发展的影响。

1.    Yifan Zhang, Qing Li, Pei-Qi Huang, Tong Su, Shu-Heng Jiang, Yue Sun, Li-peng Hu, Xueli Zhang, Xiao-mei Yang, Jun Li, Hong Pan, Lei Zhu, Lin-Li Yao, Dongxue Li, Yan-zhi Gai, Yong-Wei Sun, Zhi-Gang Zhang, De-Jun Liu*, Yanli Zhang*, Huizhen Nie*. A low amino acid environment promotes cell macropinocytosis through the YY1-FGD6 axis in Ras-mutant pancreatic ductal adenocarcinoma. Oncogene, 2022, 41(8):1203-1215.

2.    Rongkun Li, Hengchao Li, Lili Zhu, Xiaoxin Zhang, Dejun Liu, Qing Li, Bo Ni, Lipeng Hu, Zhi-Gang Zhang, Yanli Zhang*, Xu Wang*, Shu-Heng Jiang*, Reciprocal Regulation of LOXL2 and HIF1α Drives the Warburg Effect to Support Pancreatic Cancer Aggressiveness. Cell Death & Disease, 2021, 12:1106.

3.    Xue-Li Zhang, Li-Peng Hu, Qin Yang, Wei-Ting Qin, Xu Wang, Chun-Jie Xu, Guang-Ang Tian1 Xiao-Mei Yang, Lin-Li Yao, Lei Zhu, Hui-Zhen Nie, Qing Li, Qing Xu, Zhi-Gang Zhang, Yan-Li Zhang*, Jun Li*, Ya-Hui Wang*, Shu-Heng Jiang*, CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages through physical interactions with TGF-βreceptors in colorectal cancer. Oncogene, 2021, 40(23):3959-3973.

4.    Y.L. Zhang#, Q. Li#, X.M. Yang#, F. Fang, J. Li, Y.H. Wang, Q. Yang, L. Zhu, H.Z. Nie, X.L. Zhang, M.X. Feng, S.H. Jiang, G.A. Tian, L.P. Hu, H.Y. Lee, S.J. Lee, Q. Xia, Z.G. Zhang, SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways, (Highlighted Article). Cancer Res. 2018. 78(9): 2305-2317.

5.    Y.L. Zhang#, X. Xing#, L.B. Cai#, L. Zhu, X.M. Yang, Y.H. Wang, Q. Yang, H.Z. Nie, Z.G. Zhang, J. Li, X.L. Zhang. Integrin a9 suppresses hepatocellular carcinoma metastasis by Rho GTPase signaling. J Immunol Res. 2018: 4602570.

6.    Qin Yang#, Chunchao Zhu#, Yanli Zhang#, Yangyang Wang#, Yahui Wang, Lei Zhu, Xiaomei Yang, Jun Li, Huizhen Nie, Shuheng Jiang, Xiaoxin Zhang, Xiaoyan Cao, Qing Li, Xueli Zhang, Guangang Tian, Lipeng Hu, Lili Zhu, Gang Zhao, Zhigang Zhang, Molecular analysis of gastric cancer identifies genomic markers of drug sensitivity in Asian gastric cancer, Journal of Cancer, 2018; 9(16): 2973-2980.

7.    Y. Zhang, H. Wang, D. Wen, J. Zhang, F. Zheng, N. Jiang, D. Ma, Tissue factor pathway inhibitor-2 is critical in zebrafish cardiogenesis, Biochem Biophys Res Commun. 2015; 456(3):827-833.

8.    Y. Zhang, L. Wang, W. Zhou, H. Wang, J. Zhang, S. Deng, W. Li, H. Li, Z. Mao, D. Ma, Tissue factor pathway inhibitor-2: a novel gene involved in zebrafish central nervous system development, Dev Biol. 2013, 381(1): 38-49.

1.    国家自然科学基金面上项目, 2023/01-2026/12，在研，主持

2.    上海市卫生健康委员会临床研究专项，2021/01-2023/12, 已结题，主持

3.    国家自然科学基金面上项目, 2019/01-2022/12，已结题，主持

4.    国家自然科学基金青年项目, 2016/01-2018/12，已结题，主持

5.    上海市自然科学基金项目，2015/01-2017/12，已结题，主持