2010年7月毕业于上海交通大学医学院，获病理学博士学位。毕业后在上海交通大学医学院附属仁济医院上海市肿瘤研究所癌基因与相关基因国家重点实验室工作。承担国家自然科学基金、上海市自然科学基金和教育部博士点基金等多项课题。参与发表SCI论文20余篇，作为第一作者或通讯作者在Hepatology、Cancer Research、Oncogene、Cancer Letters、Carcinogenesis、 Int J Cancer等杂志发表多篇SCI论文。

调控肿瘤恶性生物学功能的新靶点及靶向治疗

调控肿瘤发生发展的关键信号转导网络

1.    Su Y, Meng L, Ge C, Liu Y, Zhang C, Yang Y, Tian W*, Tian H*. PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling. J Exp Clin Cancer Res. 2024;43(1):142.

2.    Zhou Q, Qi F, Zhou C, Ji J, Jiang J, Wang C, Zhao Q, Jin Y, Wu J, Cai Q, Tian H*, Zhang J*. VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner. Oncogene. 2024;43(2):106-122.

3.    Zhou Q, Tian W, Jiang Z, Huang T, Ge C, Liu T, Zhao F, Chen T, Cui Y, Li H, Yao M, Li J, Tian H*. A Positive Feedback Loop of AKR1C3-Mediated Activation of NF-κB and STAT3 Facilitates Proliferation and Metastasis in Hepatocellular Carcinoma. Cancer Res, 2021;81(5):1361-1374.

4.    Zhou Q, Li J, Ge C, Chen J, Tian W, Tian H*. SNX5 suppresses clear cell renal cell carcinoma progression by inducing CD44 internalization and epithelial-to-mesenchymal transition. Mol Ther Oncolytics. 2021;24:87-100.

5.    Sun T, Wei L, Tian H, Zhan W, Ma H, Nie D, Wang S, Chen X, Tang G.Novel PET/CT tracers for targeted imaging of membrane receptors to evaluate cardiomyocyte apoptosis and tissue repair process in a rat model of myocardial infarction. Apoptosis. 2021;26(7-8):460-473.

6.    Zhou Q, Huang T, Jiang Z, Ge C, Chen X, Zhang L, Zhao F, Zhu M, Chen T, Cui Y, Li H, Yao M, Li J, Tian H*. Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway. Oncogene. 2020;39(10):2140-2155.

7.    Cao Y, Wang J, Tian H*, Fu GH*. Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer.J Exp Clin Cancer Res. 2020;39(1):119.

8.    Wei L, Zhou Q, Tian H*, Su Y, Fu GH, Sun T*. Integrin β3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways. Int J Biol Sci. 2020;16(4):644-654.

9.    Jiang Z, Zhou Q, Ge C, Yang J, Li H, Chen T, Xie H, Cui Y, Shao M, Li J, Tian H*. Rpn10 promotes tumor progression by regulating hypoxia-inducible factor 1 alpha through the PTEN/Akt signaling pathway in hepatocellular carcinoma. Cancer Lett. 2019;447:1-11.

10.    Hou H, Ge C, Sun H, Li H, Li J, Tian H*.Tunicamycin inhibits cell proliferation and migration in hepatocellular carcinoma through suppression of CD44s and the ERK1/2 pathway. Cancer Sci. 2018;109(4):1088-1100.

11.    Tian H, Ge C, Zhao F, Zhu M, Zhang L, Huo Q, Li H, Chen T, Xie H, Cui Y, Yao M, Li J*.Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma. Carcinogenesis. 2017;38(2):207-217.

12.    Tian H, Ge C, Li H, Zhao F, Hou H, Chen T, Jiang G, Xie H, Cui Y, Yao M, Li J*.Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma.Hepatology. 2014;59(4):1459-70.

1.    国家自然科学基金，2023-2026

2.    国家自然科学基金，2020-2023

3.    国家自然科学基金，2015-2018

4.    上海市自然科学基金，2012-2015

5.    国家自然科学基金，2021-2024 （田伟）

6.    国家自然科学基金，2024-2026 （杨月）

7.    扬帆计划，2021-2014（田伟）

2024，专利号CN112961916B

2024，专利号CN112824540B

工作人员

田伟，哈尔滨医科大学博士，助理研究员

杨月，美国纽约州立大学上州医科大学博士，助理研究员

研究生

张驰，上海交通大学医学院，肿瘤学专业，博士生

刘钰淇，上海交通大学医学院，肿瘤学专业，硕士生

黄志宏，上海交通大学医学院，肿瘤学专业，硕士生

张灿雪，上海交通大学医学院，肿瘤学专业，硕士生