
研究员

姓名 | 王博石 | 性别 | 男 |
专家类别 | |||
学历 | 博士 | 职称 | 研究员,硕士生导师 |
联系电话 | 021-34206043 | 电子邮箱 | wbs137@@126.com; wbs137@@shsci.org |
通讯地址 | 上海市闵行区东川路800号文选医学大楼419室 |
个人简介
2012年毕业于北京协和医学院,获理学博士学位。2012年进入上海市肿瘤研究所工作,目前从事肿瘤表观基因组研究。现担任青年课题组长、硕士研究生导师。以通讯作者或第一作者身份在多种SCI期刊发表研究论文,包括Nature Communications(3篇)、EBioMedicine、Cancer Letters(3篇)、J Exp Clin Cancer Res和Oncogene等权威杂志。主持5项国家自然科学基金和1项上海市自然科学基金。曾入选上海市“启明星”计划和上海市卫生系统新优青人才培养计划。
研究方向
肿瘤表观基因组和基因表达调控
科研论文
1. Tiantian Jing, Dianhui Wei, Xiaoli Xu, Chengsi Wu, Lili Yuan, Yiwen Huang, Yizhen Liu, Yanyi Jiang, Boshi Wang. Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma. Nature Communications. 2024 Jul 4;15(1):5631. (通讯作者)
2. Dianhui Wei, Lili Yuan, Xiaoli Xu, Chengsi Wu, Yiwen Huang, Lili Zhang, Jilong Zhang, Tiantian Jing, Yizhen Liu, Boshi Wang. Exploring Epigenetic Dynamics Unveils a Super-Enhancer-Mediated NDRG1-β-Catenin Axis in Modulating Gemcitabine Resistance in Pancreatic Cancer. Cancer Letters. 2024 Oct 2:605:217284. (通讯作者)
3. Tiantian Jing, Xiaoli Xu, Chengsi Wu, Dianhui Wei, Lili Yuan, Yiwen Huang, Yizhen Liu, Boshi Wang. POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target. Cancer Letters. 2023 Nov 28:577:216444. (通讯作者)
4. Shuai Kong, Huaguang Pan, Yuan-Wei Zhang, Fei Wang, Jian Chen, Jinxiu Dong, Chuntong Yin, Jiaqi Wu, Dan Zhou, Jingyi Peng, Junboya Ma, Jianian Zhou, Dianlong Ge, Yan Lu, Dan-Dan Wei, Jinman Fang, Wei Han, Chengyin Shen, H Phillip Koeffler, Boshi Wang, Yuan Jiang, Yan-Yi Jiang. Targeting aldehyde dehydrogenase ALDH3A1 increases ferroptosis vulnerability in squamous cancer. Oncogene. 2025 Jan 25. (共同通讯作者)
5. Chengsi Wu, Yizhen Liu, Dianhui Wei, Li Tao, Lili Yuan, Tiantian Jing, Boshi Wang. Gene Coexpression Network Characterizing Microenvironmental Heterogeneity and Intercellular Communication in Pancreatic Ductal Adenocarcinoma: Implications of Prognostic Significance and Therapeutic Target. Frontiers in Oncology. 2022 Jun 1;12:840474. (通讯作者)
6. Boshi Wang, Aihui Ma, Li Zhang, Weilin Jin, Yu Qian, Guiqin Xu, Bijun Qiu; Zhaojuan Yang, Yun Liu, Qiang Xia, Yongzhong Liu, POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation, Nature Communications, 2015. 6: 8704. (第一作者)
7. Boshi Wang, Xiaoli Xu, Zhaojuan Yang, Li Zhang, Yun Liu, Aihui Ma, Guiqin Xu, Ming Tang, Tiantian Jing, Lin Wu, Yongzhong Liu. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. EBioMedicine, 2019 Mar, 41: 320-332. (第一作者)
8. Boshi Wang, Tiantian Jing, Weilin Jin, Jinnan Chen, Chengsi Wu, Mingrong Wang, Yizhen Liu, KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma. J Exp Clin Cancer Res. 2020 Aug 27;39(1):170. (第一作者,共同通讯作者)
9. Zhaojuan Yang, Guiqin Xu, Boshi Wang, Yun Liu, Li Zhang, Tiantian Jing, Ming Tang, Xiaoli Xu, Kun Jiao, Lvzhu Xiang, Yujie Fu, Daoqiang Tang, Xiaoren Zhang, Weilin Jin, Guanglei Zhuang, Xiaojing Zhao, Yongzhong Liu. USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. Nature Communications. 2021 Aug 11;12(1):4852. (共同第一作者)
10.Xiaoli Xu, Boshi Wang, Yun Liu, Tiantian Jing, Guiqin Xu, Li Zhang, Kun jiao, Zehong Chen, Lvzhu Xiang, Chen Xu, Zhaojuan Yang, Yongzhong Liu, ETV4 potentiates nuclear YAP retention and activities to enhance the progression of hepatocellular carcinoma. Cancer Letters. 2022 Jul 1:537:215640. (共同第一作者)
11.Hui Hu, Boshi Wang, Chunyu Jiang, Ruiting Li, Jungong Zhao. Endothelial progenitor cell-derived exosomes facilitate vascular endothelial cell repair through shuttling miR-21-5p to modulate Thrombospondin-1 expression. Clinical Science, 2019 Jul, 133:1629–1644. (共同第一作者)
科研项目
1. 国家自然科学基金面上项目,2024.01-2027.12
2. 国家自然科学基金面上项目,2022.01-2025.12
3. 国家自然科学基金面上项目,2020.01-2023.12
4. 国家自然科学基金面上项目, 2017.01-2020.12
5. 国家自然科学基金青年项目, 2014.01-2016.12
6. 上海市青年科技启明星计划, 2017.04-2020.03
7. 上海市卫生系统优秀青年人才培养计划,2017.07-2020.06
8. 上海交通大学医工交叉研究基金, 2018.01-2020.12
获得专利
实验室成员
景甜甜,博士,助理研究员
毕业于上海交通大学医学院
在Nature Communications、Cancer Letters等杂志发表多篇论文
主持国家自然科学基金青年项目。
徐晓莉,博士,助理研究员
毕业于上海交通大学生物医学工程学院
在Cancer letters、EbioMedicine、Nature Communications等杂志发表多篇论文
主持国家自然科学基金青年项目。