汪惠，博士，副研究员，硕士生导师，上海市肿瘤研究所青年PI。2011年博士毕业于中山大学肿瘤防治中心，分子医学专业。研究方向聚焦肝癌基础与临床转化研究，针对目前中晚期肝癌缺乏有效靶点且临床一线药物疗效不理想的核心科学问题，开展系列探索研究。近年来，以第一/通讯作者在Gastroenterology、Gut、eLife、Molecular Cancer、Cancer Letters等学术期刊发表多篇SCI论文。以项目负责人主持国家自然科学基金3项、上海市自然科学基金2项、上海市卫健委卫生行业临床研究专项面上项目1项。

肝癌治疗靶点与治疗策略的探索及应用

1.    Wang H#, Yuan S#, Zheng Q#, Zhang S#, Zhang Q, Ji S, Wang W, Cao Y, Guo Y, Yang X, Geng H, Yang F, Xi S, Jin G, Zhang J, Gao Q, Bernards R*, Qin W*, Wang C*. Dual inhibition of CDK4/6 and XPO1 induces senescence with acquired vulnerability to CRBN-based PROTAC drugs. Gastroenterology. (In press, 2024)

2.    Yang C#, Zhang H#, Chen M#, Wang S#, Qian R, Zhang L, Huang X, Wang J, Liu Z, Qin W, Wang C*, Hang H*, Wang H*. A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer. eLife. 2022; 11:e71880.

3.    He J#, Zuo Q#, Hu B#, Jin H, Wang C, Cheng Z, Deng X, Yang C, Ruan H, Yu C, Zhao F, Yao M, Fang J, Gu J, Zhou J, Fan J, Qin W, Yang X*, Wang H*. A novel liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA. Cancer Letters. 2019; 450:98-109.

4.    Wang H#, Liang L#, Dong Q#, Huan L, He J, Li B, Yang C, Jin H, Wei L, Yu C, Zhao F, Li J, Yao M, Qin W*, Qin L*, He X*. Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1NF魏B pathway in hepatocellular carcinoma. Theranostics. 2018; 8(10):2814-2829.

5.    Wang H#, Huo X, Yang X, He J, Cheng L, Wang N, Deng X, Jin H, Wang N, Wang C, Zhao F1, Fang J, Yao M, Fan J*, Qin W*. STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. Mol Cancer. 2017; 16(1):136.

6.    Yang C#, Chen J#, Li Y#, Huang X, Liu Z, Wang J, Jiang H, Qin W, Lv Y*, Wang H*, Wang C*. Exploring subclass-specific therapeutic agents for hepatocellular carcinoma by informatics guided drug screen. Briefings in Bioinformatics. 2021; 22(4):bbaa295.

7.    Wang C#, Wang H#, Lieftink C#, Chatinier A, Gao D, Jin G, Jin H, Beijersbergen RL, Qin W*, Bernards R*. CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma. Gut. 2020; 69(4):727-736.

8.    Cheng Z#, Lu C#, Wang H#, Wang N, Cui S, Yu C, Wang C, Zuo Q, Wang S, Lv Y, Yao M, Jiang L, Qin W. Long noncoding RNA LHFPL3-AS2 suppresses metastasis of non-small cell lung cancer by interacting with SFPQ to regulate TXNIP expression. Cancer Letters. 2022; 531:1-13.

9.    Chen D#, Wang H#, Chen J, Li Z, Li S, Hu Z, Huang S, Zhao Y*, He X*. MicroRNA-129-5p regulates glycolysis and cell proliferation by targeting the glucose transporter SLC2A3 in gastric cancer cells. Front Pharmacol. 2018; 9:502.

1.    国家自然科学基金面上项目, 2023/01-2026/12，在研，主持

2.    国家自然科学基金面上项目, 2020/01-2023/12，已结题，主持

3.    国家自然科学基金青年项目, 2013/01-2015/12，已结题，主持

4.    上海市自然科学基金项目，2022/04-2025/03，在研，主持

5.    上海市自然科学基金项目，2019/07-2022/06，已结题，主持

6.    上海市卫生健康委员会临床研究专项，2022/01-2024/12, 在研，主持