2007 年毕业于复旦大学上海医学院，获得免疫学医学博士学位。2008 年至 2011 年在美国匹兹堡大学医学中心（UPMC）从事博士后研究工作。2011 年底回国进入上海市肿瘤研究所，现任癌基因与相关基因国家重点实验室研究员，上海交通大学医学院博士研究生导师。近年来专注于肿瘤免疫的系统性调控研究，先后主持国家自然科学基金、教育部博士点基金项目、上海市教委科研创新重点项目等多项课题；作为项目骨干参与国家科技重大专项，国家重点研发计划“精准医学研究”专项，国家自然科学基金等多项国家和省部级课题。累计参与发表SCI论文60余篇，以第一、共同第一或通讯作者在Hepatology、Cancer Research、Annals of Neurology等国际权威杂志发表SCI论文近30篇，单篇最高引用200余次，并参编英文论著3部。

肿瘤的系统性调控

代表性论著：

1.    Liu T*, Li J*, Li Q*, Liang Y, Gao J, Meng Z, Li P, Yao M, Gu J#, Tu H#, Gan Y#. Environmental eustress promotes liver regeneration via the sympathetic regulation of type 1 innate lymphoid cells to increase IL-22 in mice. Hepatology. 2023 Jan 13. doi: 10.1097/HEP.0000000000000239. Online ahead of print.

2.    Zhao D*, Yuan H*, Fang Y, Gao J, Li H, Li M, Cong H, Zhang C, Liang Y, Li J, Yang H, Yao M, Du M#, Tu H#, Gan Y#. Histone Methyltransferase KMT2B Promotes Metastasis and Angiogenesis of Cervical Cancer by Upregulating EGF Expression. Int J Biol Sci. 2023 19:34-49.

3.    Li J*, Zhang W*, Gao J, Du M, Li H, Li M, Cong H, Fang Y, Liang Y, Zhao D, Xiang G, Ma X, Yao M, Tu H#, Gan Y#. E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1. Front Oncol. 2021 11:634167.

4.   Yang C*, Yuan H*, Gu J, Xu D, Wang M, Qiao J, Yang X, Zhang J, Yao M, Gu J, Tu H#, Gan Y#. ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway. Cell Death Discov. 2021 7(1):6.

5.    Meng Z*, Liu T*, Song Y, Wang Q, Xu D, Jiang J, Li M, Qiao J, Luo X, Gu J, Tu H#, Gan Y#. Exposure to an enriched environment promotes the terminal maturation and proliferation of natural killer cells in mice. Brain Behav Immun. 2019 77:150-160.

6.    Jiang J*, Fan Y*, Zhang W, Shen Y, Liu T, Yao M, Gu J, Tu H#, Gan Y#. Adiponectin suppresses human pancreatic cancer growth through attenuating the β-catenin signaling pathway. Int J Biol Sci. 2019 15(2):253-264.

7.   Song Y*, Gan Y*，#, Wang Q, Meng Z, Li G, Shen Y, Wu Y, Li P, Yao M, Gu J, Tu H#. Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerves-Dependent Regulation of NKG2D and CCR5. Cancer Res. 2017 77(7):1611-22.

8.    Wu Y*, Gan Y*, Yuan H, Wang Q, Fan Y, Li G, Zhang J, Yao M, Gu J, Tu H#. Enriched environment housing enhances the sensitivity of mouse pancreatic cancer to chemotherapeutic agents. Biochem Biophys Res Commun. 2016 473(2):593-9.

9.  Lin C, Wang S, Xie W, Chang J#, Gan Y#. The RET fusion gene and its correlation with demographic and clinicopathological features of non-small cell lung cancer: a meta-analysis. Cancer Biol Ther. 2015 16(7): 1019-28. (*co-corresponding author)

10. Fan Y*, Gan Y*, Shen Y, Cai X, Song Y, Zhao F, Yao M, Gu J, Tu H#. Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production. Oncotarget. 2015 6(18): 16120-34.

11. Li G*, Gan Y*, Fan Y, Wu Y, Lin H, Song Y, Cai X, Yu X, Pan W, Yao M, Gu J, Tu H#. Enriched environment inhibits mouse pancreatic cancer growth and down-regulates the expression of mitochondria-related genes in cancer cells. Sci Rep. 2015 5:7856.

12. Li P*, Gan Y*, Sun BL, Zhang F, Lu B, Gao Y, Liang W, Thomson LA, Chen J# and Hu X#. Adoptive regulatory T cell therapy protects against cerebral ischemia. Ann Neurol. 2013 74(3):458-71.

13. Gan Y, Jing Z, Stetler RA, Chen J and Cao G#. Gene delivery with viral vectors for cerebrovascular diseases. Front Biosci. (Elite Ed). 2013 5:188-203.

14. Gan Y*, Xing J*, Jing Z, Stetler RA, Zhang F, Luo Y, Ji X, Gao Y, Cao G#. Mutant erythropoietin without erythopoietic activity is neuroprotective against ischemic brain injury. Stroke. 2012 43(11):3071-7.

15. Gan Y*, Ji X#, Hu X, Luo Y, Zhang L, Li P, Liu X, Yan F, Vosler PS, Gao Y, Stetler RA, Chen J. Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway. Antioxid Redox Signal. 2012 17(5):719-32.

16. Gan Y, Zhao X, Hu J, Wang Z, Zhao XT#. HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality. Cell Death Differ. 2008; 15(9): 1481-1490.

17. Gan Y*, Gu J*, Cai X*, Hu J, Liu XY，Zhao XT#. Adenovirus-mediated HCCS1 overexpression elicits a potent anti-tumor efficacy on human colorectal cancer and hepatoma cells both in vitro and in vivo. Cancer Gene Ther. 2008; 15(12): 808-816.

1.    国家自然科学基金面上项目，82073406，能量限制联合良性心理应激增强NK细胞抗肿瘤活性并抑制其衰竭的机制研究，2021-01至2024-12

2.    国家重点研发计划精准医学研究专项，2017YFC0908103，“肝癌/肝病临床和社区人群大型队列研究“子课题“肝癌相关肝炎/肝硬化临床队列研究”，2017-07至2020-12

3.    国家科技部“十三五”科技重大专项，2017ZX10201201-008-003，“艾滋病和病毒性肝炎等重大传染病防治”子课题“不同危险度乙肝重点人群干预策略的研究与应用效果评价”，2017-01至2020-12

4.    国家自然科学基金面上项目，81571618，丰富生存环境增强NK细胞抗肿瘤免疫的作用及机制研究，2016-01至2019-12

5.    国家自然科学基金青年基金项目，81201823、良性心理应激抑制肿瘤作用及其免疫调控机制：基于丰富生存环境小鼠肿瘤模型的研究，2013-01至2015-12

6.    教育部，高等学校博士学科点专项科研基金，20120073120094，脂肪因子Leptin和Adiponectin对胰腺癌发生发展的影响及机制研究、2013-01至2015-12

高见 博士，助理研究员

李倩 博士，助理研究员