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研究员

姓名 李锦军 性别
专家类别 新世纪百千万人才工程国家级人才
学历 博士 职称 研究员
联系电话 021-64432140 电子邮箱 jjli@@shsci.org
通讯地址 上海市斜土路2200弄25号
个人简介

1997年获日本国立山口大学博士学位,现任上海市肿瘤研究所癌基因及相关基因国家重点实验室研究团队负责人,是上海市医学会肿瘤靶分子专业委员会委员、肿瘤专业委员会委员。目前承担国家自然科学基金面上项目2项、“十二五”国家科技重大专项课题1项,参加973项目1项。2011至2015年期间,发表SCI论文39篇(其中通讯作者13篇,包括2篇Hepatology、1篇Cancer Res、1篇Mol Cancer Therap杂志文章),参编专著1部。申报国家发明专利12项(其中6项已授权)。2006年享受国务院特殊津贴,2009年入选市优秀学科带头人培养计划(A类)、上海领军人才“地方”培养计划,“新世纪百千万人才工程”国家级人才培养计划。2012年开始任上海市政协委员。

研究方向

1.肝癌干细胞的靶向治疗临床基础研究;

2.肝癌耐药分子机制研究;

3.肿瘤转移分子机制研究。

科研论文

1.  Jiang J*, Liu Z*, Ge C, Chen C, Zhao F, Li H, Chen T, Yao M, Li J#. NK3 Homeobox 1 (NKX3.1) Upregulates Forkhead Box O1 Expression in Hepatocellular Carcinoma and Thereby Suppresses Tumor Proliferation and Invasion. J Biol Chem 292(47) 19146–19159, 2017

2.  Yi-Yao Liu, Chao Ge, Hua Tian, Jing-Yi Jiang, Fang-Yu Zhao, Hong Li, Tao-Yang Chen, Ming Yao, Jin-Jun Li#. The transcription factor Ikaros inhibits cell proliferation by downregulating ANXA4 expression in hepatocellular carcinoma. Am J Cancer Res 7(6): 1285-1297, 2017

3.  Huo Q, Ge C, Tian H, Sun J, Cui M, Li H, Zhao F, Chen T, Xie H, Cui Y, Yao M, Li J#. Dysfunction of IKZF1/MYC/MDIG axis contributes to liver cancer progression through regulating H3K9me3/p21 activity. Cell Death Dis. 8(5):e2766, 2017

4.  Hua Tian, Chao Ge, Fangyu Zhao, Miaoxin Zhu, Lin Zhang, Qi Huo, Hong Li, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li#. Downregulation of AZGP1 by Ikaros and histone deacetylase promotes metastasis through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma. Carcinogenesis 38 (2): 207-217, 2017

5.  Yang Zhang*, Li-Xing Zhang*, Xiao-Qin Liu, Fang-Yu Zhao, Chao Ge, Tao-Yang Chen, Ming Yao and Jin-Jun Li#. Id-4 promotes cell proliferation in hepatocellular carcinoma. Chin J Cancer 36:19, 2017

6.  Zhang L, Ge C, Zhao F, Zhang Y, Wang X, Yao M, Li J#. NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling. Cancer Res 76(23): 7059-71, 2016

7.  Lin Zhang*, Hong Li*, Chao Ge, Meng Li, Fang-yu Zhao, He-lei Hou, Miao-xin Zhu, Hua Tian, Li-xing Zhang, Tao-yang Chen, Guo-ping Jiang, Hai-yang Xie, Ying Cui, Ming Yao and Jin-jun Li#. Inhibitory effects of transcription factor Ikaros on the expression of liver cancer stem cell marker CD133 in hepatocellular carcinoma. Oncotarget 5(21):10621-10635, 2014

8.  Hua Tian, Chao Ge, Hong Li, Fangyu Zhao, Helei Hou, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li#. Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma. Hepatology 59(4): 1459-1470, 2014

9.  Helei Hou, Hefen Sun, Ping Lu, Chao Ge, Lixing Zhang, Hong Li, Fangyu Zhao, Hua Tian, Lin Zhang, Taoyang Chen, Ming Yao, Jinjun Li#. Tunicamycin potentiates cisplatin anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse xenograft models of human hepatocellular carcinoma. Mol Cancer Therap  12(12): 2874-2884, 2013

10.  Lixing Zhang, Hefen Sun, Fangyu Zhao, Ping Lu, Chao Ge, Hong Li, Helei Hou, Mingxia Yan, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Xiaowu Huang, Jia Fan, Ming Yao, Jinjun Li#. BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocelluar carcinoma. Cancer Res 72(16): 4276-4285, 2012

11.  Hong Li, Chao Ge, Fangyu Zhao, Mingxia Yan, Chen Hu, Deshui Jia, Hua Tian, Miaoxin Zhu,Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Jianren Gu, Hong Tu, Xianghuo He, Ming Yao, Yongzhong Liu, Jinjun Li#. HIF-1α-activated ANGPTL4 contributes to tumor metastasis via VCAM-1/integrin β1 signaling in human hepatocellular carcinoma. Hepatology 54(3): 910-919, 2011

12.  Feng Yu*, Xiangfang Hao*, Heng Zhao, Chao Ge, Ming Yao, Shengli Yang#, Jinjun Li#. DLK1 contributes to cell growth by increasing IFI16 expression in hepatocellular carcinoma. Liver International 30(5): 703-714, 2010

13.  Zheng Zhu*, Xiangfang Hao*, Mingxia Yan, Ming Yao, Chao Ge, Jianren Gu, Jinjun Li#. Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma. Int J Cancer 126(9): 2067-2078, 2010

14.  Chen Hu*, Hong Li*, Jin-Jun Li#, Zheng Zhu, Sheng-Yong Yin, Xiang-Fang Hao, Ming Yao, Shu-Sen Zheng, Jian-Ren Gu. Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling. Carcinogenesis, 29(12): 2289-2297, 2008.

15.  Zhu L*, Hu C*, Li J#, Xue P, He X, Ge C, Qin W, Yao G, Gu J. Real-time imaging nuclear translocation of Akt1 in HCC cells. Biochem Biophys Res Commun 356(4):1038-1043, 2007

16.  Yin S*, Li J*, Hu C, Chen X, Yao M, Yan M, Jiang G, Ge C, Xie H, Wan D, Yang S, Zheng S#, Gu J#. CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer  120(7):1444-1450, 2007  


科研项目

1. 国家自然科学基金面上项目“IKZF1/CD133/MINA53信号通路在维持肝癌干细胞干性中的作用和机制研究”(81773152)2018.1-2021.12,55万元,主持。

2. 国家自然科学基金面上项目“转录因子Ikaros在抑制肝癌干细胞增殖中的功能和分子机制研究”(81472726)2015.1-2018.12,72万元,主持。

3. 国家自然科学基金面上项目“天然生物碱ISO-X/ICD 选择性杀伤肝癌干细胞作用及机制研究”(81272438)2013.1-2016.12,70万元,主持。

4. 国家科技重大专项课题“解决肝癌耐药的新策略研究”(2013ZX10002011)2013.1-2015.12,500万元,主持。

5. 国家自然科学基金委及香港研究资助局联合研究计划“人肝细胞癌Wnt/beta-catenin信号传导调控分子的研究”(30731160004)2007.1-2009.12,35万元,主持。


获得专利
实验室成员

工作人员:

      邵苗苗  博士  助理研究员

      葛  超  本科  主管技师

博士研究生:

      陈  聪 博士生

      杨  静 博士生

      张莉莉 博士生

      刘  征 硕士生

      李亮宇 硕士生

李锦军组合影_副本.jpg

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