杨小妹，博士，副研究员。 2003毕业于南京大学与中国药科大学联办的生物制药强化班专业，获得理学学士学位； 2010年于中科院上海生命科学研究院硕博连读，从事肿瘤微环境与肿瘤进展方面的研究，获得博士学位。2010年至今，于上海交通大学医学院附属仁济医院上海市肿瘤研究所“神经递质与肿瘤微环境”实验室工作，历任助理研究员，副研究员，硕导，青年PI。长期从事肝癌与胰腺癌的发生发展的分子机制研究，近年来研究成果主要发表于Gastroenterology，Clin Transl Med，Cancer Research，Journal of Hepatology, Cancer Science, Cellular Oncology, iScience等国际著名期刊。参与翻译“肿瘤微环境”著作1本。主持多项国家自然科学基金、上海市科委基金以及上海市卫生计划委员会面上项目，并作为主要骨干人员参与“十二五”重大专项子课题一项。作为第五完成人获得2019年上海市医学科技奖二等奖。

1. 肿瘤的恶性进展分子机制和靶向策略

2. 蛋白翻译后修饰、细胞代谢稳态和器官功能

1. Wu Z#, Ye Q#, Zhang S#, Hu LP, Wang XQ, Yao LL, Zhu L, Xiao SY, Duan ZH, Zhang XL, Jiang SH, Zhang ZG, Liu DJ*, Li DX*, Yang XM*. Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR. Clin Transl Med. 2025 Jan;15(1):e70191.

2. Xing X#, Li XQ#, Yin SQ#, Ma HT, Xiao SY, Tulamaiti A, Yang Y, Jiang SH, Hu LP, Zhang ZG, Huo YM, Li DX*, Yang XM*, Zhang XL*. OASL promotes immune evasion in pancreatic ductal adenocarcinoma by enhancing autolysosome-mediated degradation of MHC-I. Theranostics. 2025 Jan 13;15(6):2104-2120.

3. Yao LL#, Qin WT#, Hu LP#, Shi TZ#, Yu Yang J, Li Q, Nie HZ, Li J, Wang X, Zhu L, Liu DJ, Zhang YL, Jiang SH, Zhang ZG, Yang XM*, Li DX*, Zhang XL*. Reciprocal tumor-platelet interaction through the EPHB1-EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma. Cancer Commun (Lond). 2025 Feb;45(2):143-166.

4. Yang XM#, Wang XQ#, Hu LP#, Feng MX, Zhou YQ, Li DX, Li J, Miao XC, Zhang YL, Yao LL, Nie HZ, Huang S, Xia Q, Zhang XL*, Jiang SH*, Zhang ZG*. Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis. Gastroenterology. 2023 Sep;165(3):629-646.

5. Zhang S#, Yao HF#, Li H#, Su T#, Jiang SH, Wang H, Zhang ZG*, Dong FY*, Yang Q*, Yang XM*.  Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic cancer. Cell Oncol (Dordr). 2023 Oct;46(5):1473-1492.

6. Lin L#, Li X#, Wu AJ#, Xiu JB, Gan YZ, Yang XM*, Ai ZH*. TRPV4 enhances the synthesis of fatty acids to drive the progression of ovarian cancer through the calcium-mTORC1/SREBP1 signaling pathway. iScience. 2023 Oct 18;26(11):108226.

7. Zhu L#, Zhou KX#, Ma MZ#, Yao LL, Zhang YL, Li H*, Du C*, Yang XM*. Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation. J Immunol Res. 2022 Jun 19;2022:1590717.

8. Yang XM#, Wu Z#, Wang X#, Zhou Y, Zhu L, Li D, Nie HZ, Wang YH, Li J*, Ma X*. Disulfiram inhibits liver fibrosis in rats by suppressing hepatic stellate cell activation and viability. BMC Pharmacol Toxicol. 2022 Jul 22;23(1):54.

9. Wu A#, Lin L#, Li X#, Xu Q, Xu W, Zhu X, Teng Y, Yang XM*, Ai Z*. Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis. Cancer Sci. 2021 Nov;112(11):4515-4525.

 10.Yang XM#, Cao XY#, He P#, Li J, Feng MX, Zhang YL, Wang YH, Yang Q, Zhu L, Nie HZ, Jiang SH, Tian GA, Zhang XX, Liu Q, Ji J, Zhu X, Xia Q*, Zhang ZG*. Overexpression of Rac GTPase activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis, Gastroenterology 2018;155:1233–1249.

 11.Zhang YL#, Li Q#, Yang XM#, Fang F, Li J,  Yang Q, Zhu L, Nie HZ, Zhang XL, Feng MX, Jiang SH, Tian GA, Hu LP, Lee HY, Lee SJ, Xia Q*, Zhang ZG*, SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways, Cancer Res.2018; 78(9):2305-2317.

 12.Li J, Yang XM, Wang YH, Feng MX, Liu XJ, Zhang YL, Huang S, Wu Z, Xue F, Qin WX, Gu JR, Xia Q, Zhang ZG. Monoamine oxidase A suppresses Hepatocellular Carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling. Journal of Hepatology, 2014 Jun;60(6):1225-34.

 13.Dou XQ, Yang XM, Li P, Zhang ZG, Schönherr H, Zhang D, Feng CL. Novel pH Responsive Hydrogels for Controlled Cell Adhesion and Triggered Surface Detachment. Soft Matter, 2012,8, 9539-9544

1. 基质硬度调控的γ-谷氨酸羧化蛋白PRRG1在胰腺导管腺癌进展中的作用机制，国家自然科学基金面上项目，82472919，2025.01-2028.12，主持

2. 核仁蛋白HEATR1通过调控核糖体合成促进肝癌发展的机制研究，国家自然科学基金面上项目，81972582，2020.01-2023.12，主持

3. Tuftelin 1 调控脂肪酸代谢促进肝癌进展的作用机制研究，上海市科委自然科学基金项目，19ZR1452500，2019.07-2022.06，主持

4. 细胞分裂关键蛋白RacGAP1促进肝癌生长的功能和机制研究，上海市卫生计划委员会面上项目，201740056，2018-01~2020-12，主持

5. 胶原样分子CTHRC1 在肝癌微环境中的功能及其分子机制，国家自然科学基金青年基金项目，81101600，2012-01~2014-12，主持

1. 徐岷涓、张志刚、徐俊、杨小妹、何昆燕、余河霖、蒋书恒. 多环稠合大环内酰胺类化合物的抗胰腺癌用途. 2019.1，中国，ZL201610372876.8

伍铮，硕士研究生，毕业于福建医科大学

叶青，硕士研究生，毕业于温州医科大学