研究组
神经递质与肿瘤微环境研究组
日期:2024-04-16研究方向
1. 肿瘤的系统性调控
2. 神经递质-激素-免疫系统对肿瘤发生发展的调控
3. 器官间交流在肿瘤发生发展中的作用
团队成员
李军 杨小妹 张雪莉 蒋书恒 张艳丽 胡立鹏 朱蕾 姚琳丽 李冬雪 李慧 杜畅 苗小草 李庆 张姗 黄杉 李坤瑀 张娇真 马筱一 杨岩
代表性论文
1. Wang X, Fu SQ, Yuan X, Yu F, Ji Q, Tang HW, Li RQ, Huang S, Huang PQ, Qin WT, Zuo H, Du C, Yao LL, Li H, Li J, Li DX, Yang Y, Xiao SY, Tulamaiti A, Wang XF, Dai CH, Zhang X, Jiang SH, Hu LP, Zhang XL, Zhang ZG*. A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity. Molecular Cell. 2024. Feb 15;84(4):760-775.e7.
2. Yang XM, Wang XQ, Hu LP, Feng MX, Zhou YQ, Li DX, Li J, Miao XC, Zhang YL, Yao LL, Nie HZ, Huang S, Xia Q, Zhang XL, Jiang SH, Zhang ZG*. Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis. Gastroenterology. 2023 May 27:S0016-5085(23)00802-8. doi: 10.1053/j.gastro.2023.05.029.
3. Li Q, Zhang XX, Hu LP, Ni B, Li DX, Wang X, Jiang SH, Li H, Yang MW, Jiang YS, Xu CJ, Zhang XL, Zhang YL, Huang PQ, Yang Q, Zhou Y, Gu JR, Xiao G GS, Sun YW, Li J, Zhang ZG*. Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma. Nature Communications, 2023 Feb 15;14(1):861. doi: 10.1038/s41467-023-36521-0.
4. Hu LP, Huang W, Wang X, Xu C, Qin WT, Li D, Tian G, Li Q, Zhou Y, Chen S, Nie HZ, Hao Y, Song J, Zhang XL, Sundquist J, Sundquist K, Li J, Jiang SH, Zhang ZG, Ji J. Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression. Molecular Therapy. 2022 Oct 5;30(10):3284-3299.
5. Wang X, Hu LP, Qin WT, Yang Q, Chen DY, Li Q, Zhou KX, Huang PQ, Xu CJ, Li J, Yao LL, Wang YH, Tian GA, Yang JY, Yang MW, Liu DJ, Sun YW, Jiang SH, Zhang XL, Zhang ZG*. Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis. Nature Communications, 2021 Jan 8; 12(1):174
6. Zhang N, Sundquist J, Sundquist K, Zhang ZG, Ji J. Combined Use of Aspirin and Selective Serotonin Reuptake Inhibitors Is Associated With Lower Risk of Colorectal Cancer: A Nested Case-Control Study. Am J Gastroenterol. 2021 Feb 26.
7. Jiang SH, Hu LP, Wang X, Li J, Zhang ZG. Neurotransmitters: emerging targets in cancer. Oncogene. 2020 Jan;39(3):503-515.
8. Yang MW, Tao LY, Jiang YS, Yang JY, Huo YM, Liu DJ, Li J, Fu XL, He R, Lin C, Liu W, Zhang JF, Hua R, Li Q, Jiang SH, Hu LP, Tian GA, Zhang XX, Niu N, Lu P, Shi J, Xiao GG, Wang LW, Xue J, Zhang ZG*, Sun YW. Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma. Cancer Research. 2020, 80, 1991-2003.
9. Jiang SH, Zhu LL, Zhang M, Li RK, Yang Q, Yan JY, Zhang C, Yang JY, Dong FY, Dai M, Hu LP, Li J, Li Q, Wang YH, Yang XM, Zhang YL, Nie HZ, Zhu L, Zhang XL, Tian GA, Zhang XX, Cao XY, Tao LY, Huang S, Jiang YS, Hua R, Luo KQ, Gu JR, Sun YW, Hou SW, Zhang ZG*. GABRP regulates chemokine signaling, macrophage recruitment, and tumor progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signaling in a GABA-independent manner. Gut, 2019 Nov;68(11):1994-2006.
10. Hu LP, Zhang XX, Jiang SH, Tao LY, Li Q, Zhu LL, Yang MW, Huo YM, Jiang YS, Tian GA, Cao XY, Zhang YL, Yang Q, Yang XM, Wang YH, Li J, Xiao GG, Sun YW, Zhang ZG*. Targeting Purinergic Receptor P2Y2 prevents the growth of pancreatic ductal adenocarcinoma by inhibiting cancer cell glycolysis. Clinical Cancer Research, 2019 Feb 15;25(4):1318-1330.
11. Yang XM, Cao XY, He P, Li J, Feng MX, Zhang YL, Zhang XL, Wang YH, Yang Q, Zhu L, Nie HZ, Jiang SH, Tian GA, Zhang XX, Liu Q, Ji J, Zhu X, Xia Q, Zhang ZG*. Overexpression of Rac GTPase activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis. Gastroenterology, 2018 Oct;155(4):1233-1249.
12. Zhang YL, Li Q, Yang XM, Fang F, Li J, Wang YH, Yang Q, Zhu L, Nie HZ, Zhang XL, Feng MX, Jiang SH, Tian GA, Hu LP, Lee HY, Lee SJ, Xia Q, Zhang ZG*, SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways. Cancer Research, 2018 May 1;78(9):2305-2317.
13. Jiang SH, Li J, Dong FY, Yang JY, Liu DJ, Yang XM, Wang YH, Yang MW, Fu XL, Zhang XX, Li Q, Pang XF, Huo YM, Li J, Zhang JF, Lee HY, Lee SJ, Qin WX, Gu JR, Sun YW, Zhang ZG*. Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice. Gastroenterology, 2017 Jul;153(1):277-291.
14. Nie H, Li J, Yang XM, Cao QZ, Feng MX, Xue F, Wei L, Qin W, Gu J, Xia Q, Zhang ZG*. Mineralocorticoid receptor suppresses cancer progression and Warburg effect by modulating miR-338-3p-PKLR axis in hepatocellular carcinoma. Hepatology, 2015 Oct;62(4):1145-59.
15. Li J, Yang XM, Wang YH, Feng MX, Liu XJ, Zhang YL, Huang S, Wu Z, Xue F, Qin WX, Gu JR, Xia Q, Zhang ZG*. Monoamine oxidase A suppresses Hepatocellular Carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling. Journal of Hepatology, 2014 Jun;60(6):1225-34.
16. Zhao SJ, Jiang YQ, Xu NW, Li Q, Zhang Q, Wang SY, Li J, Wang YH, Zhang YL, Jiang SH, Wang YJ, Huang YJ, Zhang XX, Tian GA, Zhang CC, Lv YY, Dai M, Liu F, Zhang R, Zhou D, Zhang ZG*. SPARCL1 suppresses osteosarcoma metastasis and recruits M1 macrophages by autocrine activation of canonical WNT/β-catenin signaling through stabilization of the WNT-receptor complex. Oncogene, 2018 Feb 22;37(8):1049-1061.
科研项目
1. 国家自然科学基金原创探索项目，去甲肾上腺素化修饰介导的CD8+T细胞表观遗传重编程及性别差异影响抗肿瘤免疫的研究，2024/01-1 2026/12，在研，主持
2. 国家自然科学基金重点项目，外周5-羟色胺通过受体介导或翻译后修饰的方式调控消化系统肿瘤及其微环境的分子机制研究，2023/01-2027/12，在研，主持
3. 国家自然科学基金重大研究计划培育项目, TRGel微囊化结合全组织透明化和高分辨率成像技术解析胰岛再生动态演进过程及其分子机制，2022/01-2024/12, 在研，主持
4. 国家自然科学基金面上项目，pre-mRNA剪接因子SF3B4通过可变剪接调控脂质代谢促进肝癌发展的分子机制研究，2017/01-2020/12，已结题，主持
5. 国家自然科学基金面上项目，甲基化介导的胞外基质蛋白Dermatopontin基因沉默促进肝癌的侵袭转移，2015/01-2018/12，已结题，主持
6. 国家科技重大专项子课题，指导肝癌化疗方案的单胺氧化酶（MAOA）、分泌蛋白CTHRC1血清检测试剂，2013/01-2015/12，已结题，主持
7. 国家高技术研究发展计划，胰腺癌的蛋白质分子网络研究，2014/01-2016/12，已结题，骨干
8. 国家自然科学基金面上项目，整合素α9β1在肝癌与其微环境相互作用中的研究，2011/01-2013/12，已结题，主持
获得专利等其他
1. MAOA基因在肝癌治疗中的应用，专利号：ZL201210181654.X，张志刚，李军，顾健人
2. 芳香化酶抑制剂在制备抗肝硬化或抗肝纤维化的药物中的应用，专利号：ZL 201110418167.6，张志刚，覃文新，王亚辉
招聘
实验室长期招聘博士后