课题组长

田华，医学博士，研究员，博士生导师

研究方向

调控肿瘤恶性生物学功能的新靶点及靶向治疗

调控肿瘤发生发展的关键信号转导网络

研究组成员

工作人员

田伟，哈尔滨医科大学博士，助理研究员

杨月，美国纽约州立大学上州医科大学博士，助理研究员

研究生

张驰，上海交通大学医学院，肿瘤学专业，博士生

刘钰淇，上海交通大学医学院，肿瘤学专业，硕士生

黄志宏，上海交通大学医学院，肿瘤学专业，硕士生

张灿雪，上海交通大学医学院，肿瘤学专业，硕士生

代表性论文

1.    Su Y, Meng L, Ge C, Liu Y, Zhang C, Yang Y, Tian W*, Tian H*. PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling. J Exp Clin Cancer Res. 2024;43(1):142.

2.    Zhou Q, Qi F, Zhou C, Ji J, Jiang J, Wang C, Zhao Q, Jin Y, Wu J, Cai Q, Tian H*, Zhang J*. VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner. Oncogene. 2024;43(2):106-122.

3.    Zhou Q, Tian W, Jiang Z, Huang T, Ge C, Liu T, Zhao F, Chen T, Cui Y, Li H, Yao M, Li J, Tian H*. A Positive Feedback Loop of AKR1C3-Mediated Activation of NF-κB and STAT3 Facilitates Proliferation and Metastasis in Hepatocellular Carcinoma. Cancer Res, 2021;81(5):1361-1374.

4.    Zhou Q, Li J, Ge C, Chen J, Tian W, Tian H*. SNX5 suppresses clear cell renal cell carcinoma progression by inducing CD44 internalization and epithelial-to-mesenchymal transition. Mol Ther Oncolytics. 2021;24:87-100.

5.    Sun T, Wei L, Tian H, Zhan W, Ma H, Nie D, Wang S, Chen X, Tang G.Novel PET/CT tracers for targeted imaging of membrane receptors to evaluate cardiomyocyte apoptosis and tissue repair process in a rat model of myocardial infarction. Apoptosis. 2021;26(7-8):460-473.

6.    Zhou Q, Huang T, Jiang Z, Ge C, Chen X, Zhang L, Zhao F, Zhu M, Chen T, Cui Y, Li H, Yao M, Li J, Tian H*. Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway. Oncogene. 2020;39(10):2140-2155.

7.    Cao Y, Wang J, Tian H*, Fu GH*. Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer.J Exp Clin Cancer Res. 2020;39(1):119.

8.    Wei L, Zhou Q, Tian H*, Su Y, Fu GH, Sun T*. Integrin β3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways. Int J Biol Sci. 2020;16(4):644-654.

9.    Jiang Z, Zhou Q, Ge C, Yang J, Li H, Chen T, Xie H, Cui Y, Shao M, Li J, Tian H*. Rpn10 promotes tumor progression by regulating hypoxia-inducible factor 1 alpha through the PTEN/Akt signaling pathway in hepatocellular carcinoma. Cancer Lett. 2019;447:1-11.

10.    Hou H, Ge C, Sun H, Li H, Li J, Tian H*.Tunicamycin inhibits cell proliferation and migration in hepatocellular carcinoma through suppression of CD44s and the ERK1/2 pathway. Cancer Sci. 2018;109(4):1088-1100.

11.    Tian H, Ge C, Zhao F, Zhu M, Zhang L, Huo Q, Li H, Chen T, Xie H, Cui Y, Yao M, Li J*.Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma. Carcinogenesis. 2017;38(2):207-217.

12.    Tian H, Ge C, Li H, Zhao F, Hou H, Chen T, Jiang G, Xie H, Cui Y, Yao M, Li J*.Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma.Hepatology. 2014;59(4):1459-70.

科研项目

1.    国家自然科学基金，2023-2026

2.    国家自然科学基金，2020-2023

3.    国家自然科学基金，2015-2018

4.    上海市自然科学基金，2012-2015

5.    国家自然科学基金，2021-2024 （田伟）

6.    国家自然科学基金，2024-2026 （杨月）

7.    扬帆计划，2021-2014（田伟）

获得专利

1.    2024，专利号CN112961916B.

2.    2024，专利号CN112961916B