课题组长

朱鹤，研究员，课题组长，博士生导师

研究方向

1.  前列腺癌抗雄激素耐药和肿瘤转移的发生机制和新的治疗手段（单抗和小分子）的开发

2.  前列腺组织干细胞干性调控机制和在肿瘤发生中的作用

3.  造血干细胞和白血病干细胞干性调控的分子机制

代表性论文

1.  Wang, X., Xu, H., Cheng, C., Ji Z., Zhao, H., Sheng, Y., Li, X., Wang, J., Shu, Y., He Yu., Fan, L., Dong, B., Xue, W., Chua, C.W., Wu, D., Gao, W.Q. *, Zhu, H.H.* (2020) Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate. Nature Communications. 11（1）：706

2.  Ji, Z., Sheng, Y., Miao, J., Li, X., Zhao, H., Wang, J., Cheng, C., Wang, X., Liu, K., Zhang, K., Xu, L., Yao, J., Shen, L., Hou, J., Zhou, W., Sun, J. *, Li, L. *, Gao, W.Q. *, Zhu, H.H.* (2019) The histone methyltransferase Setd2 is indispensable for V(D)J recombination. Nature Communications. 10（1）：3353

3.  Wang, X.#, Dong, B.#, Zhang, K., Ji, Z., Cheng, C., Zhao, H., Sheng, Y., Li, X., Fan, L., Xue, W., Gao, W.Q.*, Zhu, H.H.* （2018）E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo. Plos Genetics. 14(8): e1007609

4.  Cheng, C. #,  Ji, Z. #, Sheng, Y., Wang, J., Sun, Y., Zhao, H., Li, X., Wang, X., He, Y., Yao, J., Wang, L., Zhang, C., Guo, Y., Gao, W.Q.*, Zhu, H.H.* (2018) An Aphthous Ulcer Drug Inhibits Prostate Tumor Metastasis By Targeting The IKKɛ/TBK1/NF-κB Signaling. Theranostics. 8, 4633-4648

5.  Guo,Y., Zhang, K., Cheng, C., Ji, Z. , Wang, X.,  Wang, M., Chu, M., Tang, D.G., Zhu, H.H.* and Gao, W.Q.* (2017) Numb-/low enriches a castration resistant prostate cancer cell subpopulation associated with enhanced Notch and Hedgehog signaling. Clinical Cancer Research. 23:6744-6756

6.  Zhang, K., Guo, Y., Wang, X., Zhao, H., Ji, Z., Cheng, C., Li, L., Fang, Y., Xu, D., Zhu, H.H.*, and Gao, W.Q.* (2017) WNT/β-catenin Directs Self-Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem Cells. Cancer Research. 77(9):2534-2547.

7.  Guo,Y.#, Cui,J.#, Ji, Z., Cheng, C., Zhang, K., Zhang, C.,  Chu,M., Zhao, Q., Yu, Z., Zhang, Y., Fang,Y.X., Gao, W.Q.*, and  Zhu, H.H.*(2017)MiR-302/367/LATS2/YAP Pathway is Essential for Prostate Tumor-Propagating Cells and Promotes the Development of Castration Resistance. Oncogene 36:6336-6347  

8.  Zhu, H.H.*, Luo, X., Zhang, K., Cui, J., Zhao, H., Ji, Z., Zhou, Z., Yao, J., Zeng, L., Ji, K., Gao, W.Q., Zhang, Z.Y., Feng, G.S.* (2015) Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proceedings of the National Academy of Sciences of the United States of America 112: 13342-13347

9.  Zhou, Z., Ji, Z., Wang, Y., Li, J., Cao, H., Zhu, H. H.*, and Gao, W. Q.* (2014). TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53. Gastroenterology 147, 1043-1054.

10.  Zhu, H. H., Ji, K., Alderson, N., He, Z., Li, S., Liu, W., Zhang, D. E., Li, L., and Feng, G. S. (2011). Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood 117, 5350-5361.