课题组长

薛婧博士，研究员，博士生导师

研究方向

课题组以胰腺疾病为模型，主要开展以下研究：

（1） 急、慢性胰腺炎发展过程中的免疫调控及靶向研究

（2） 炎症促胰腺肿瘤发生发展的分子调控机制

（3）表观遗传元件在胰腺疾病发生发展中的功能机制研究

团队成员

牛宁宁（研究员）

路   平 （助理研究员）

刘明珠（实验助理）

孟世昕（实验助理）

博士研究生：沈叙清，翁雅雯，郁菲儿

硕士研究生：刘奕梅，张昊哲

实验室前成员：

武婧华，陈月月，许君怡 （硕士研究生，已毕业）

张   丽，石娟娟，杨晓彤，张争艳，唐莹莹（博士研究生, 已毕业）

何维志 （博士后，已出站）

实验助理： 耿静，杨艳琳，杨文娟

代表性论文

1    Xuqing Shen, Yueyue Chen, Yingying Tang, Ping Lu, Mingzhu Liu, Tiebo Mao, Yawen Weng, Feier Yu, Yimei Liu, Yujie Tang*, Liwei Wang*, Ningning Niu*, Jing Xue*. Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis. Cell Reports Medicine, 2025, accepted.

2    Zhang Z, Tang Y, Wang Y, Xu J, Yang X, Liu M, Mazzone M, Niu N, Sun Y, Tang Y, Xue J*. SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer. Adv Sci (Weinh). 2024 Nov;11(43):e2402244.

3    Feng W, Niu N, Lu P, Chen Z, Rao H, Zhang W, Ma C, Liu C, Xu Y, Gao WQ, Xue J*, Li L*. Multilevel regulation of NF-κB signaling by NSD2 suppresses Kras-driven pancreatic tumorigenesis, Advanced Science, 2024 Aug;11(30):e2309387.

4    Tang Y, Tang S, Yang W, Zhang Z, Wang T, Wu Y, Xu J, Pilarsky C, Mazzone M, Wang LW, Sun Y, Tian R, Tang Y, Wang Y, Wang C, Xue J*. MED12 loss activates endogenous retroelements to sensitise immunotherapy in pancreatic cancer.  Gut. 2024 Nov 11;73(12):1999-2011.

5    Niu N, Shen X, Wang Z, Chen Y, Weng Y, Yu F, Tang Y, Lu P, Liu M, Wang L, Sun Y, Yang M, Shen B, Jin J, Lu Z, Jiang K, Shi Y, Xue J*. Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer. Cancer Cell. 2024 May 13;42(5):869-884

6    Lu P, Xu J, Shen X, Sun J, Liu M, Niu N, Wang Q, Xue J*. Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis. Cell Rep. 2024 Feb 27;43(2):113703.

7    Yang X, Zhang Z, Shen X, Xu J, Weng Y, Wang W, Xue J*. Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma. Cell Oncol (Dordr). 2023 Dec;46(6):1645-1658.

8    Chen Y, Shen X, Tang Y, Weng Y, Yang W, Liu M, Xu D, Shi J, Yang X, Yu F, Xu J, Zhang Z, Lu P, Sun Y, Xue J*, Niu N*. The diverse pancreatic tumor cell-intrinsic response to IFNγ is determined by epigenetic heterogeneity.  Cancer Lett.2023 May 28;562:216153.

9    Niu N, Shen X, Zhang L, Chen Y, Lu P, Yang W, Liu M, Shi J, Xu D, Tang Y, Yang X, Weng Y, Zhao X, Wu LM, Sun Y, Xue J*. Tumor Cell-Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis. Adv Sci (Weinh). 2023 Jan;10(2):e2202937

10    Zhang L, Shi JJ, Du D, Niu NN, Liu SY, Yang XT, Lu P, Shen XQ, Shi N, Yao LB, Zhang RL, Hu GY, Lu GT, Zhu QT, Zeng T, Liu TT, Xia Q, Huang W*, Xue J*. Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis. EBioMedicine 2022 Apr; 78:103959.

11    Wang Y, Liang YY, Xu HY, Zhang X, Mao TB, Cui JJ, Yao JY, Wang YC, Jiao F,  Xiao XY, Hu J, Xia Q, Zhang XF,  Wang XJ,  Sun YW, Fu DL, Shen L, Xu XJ*, Xue J* and Wang LW*. Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response. Cell Discov. 2021 May 25;7(1):36.

12    Niu NN, Lu P,Yang YL, He WZ, Zhang L, Shi JJ, Wu JH, Yang MW, Zhang ZG, Wang LW, Gao WQ, Habtezion A, Xiao GG, Sun YW*, Li L*, Xue J*. Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia mesenchymal transition during pancreatic carcinogenesis. Gut. 2020 Apr;69(4):715-726

13    Yang MW, Tao LY, Jiang YS, Yang JY, Huo YM, Liu DJ, Li J, Fu XL, He RZ, Lin, CY, Liu W, Zhang JF, Hua R, Li Q, Jiang SH, Hu LP, Tian GA, Zhang XX, Niu NN, Lu P, Shi JJ, Xiao GG, Wang LW, Xue J *, Zhang ZG*, Sun YW*. Perineural invasion reprograms the immune microenvironment through cholinergic signaling in pancreatic ductal adenocarcinoma. Cancer Res. 2020 May 15;80(10):1991-2003

14    Wu JH, Zhang L, Shi JJ, He RZ, Habtezion A, Niu NN*, Lu P *, Xue J*. Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury. EBioMedicine, 2020, 58: 102920.

15    Shi JJ, Lu P, Shen WY, He RZ, Yang MW, Fang Y, Sun YW*, Niu NN *, Xue J*. CD90 highly-expressed population harbors stemness signature and creates an immunosuppressive niche in pancreatic cancer. Cancer Lett. 2019 Jul 1;453:158-169.

16    Zhang R, Shi JJ, Zhang R, Ni J, Habtezion A, Wang XP, Hu GY*, XueJ*.  ExpandedCD14hiCD16-Immunosuppressive Monocytes Predict Disease Severity in Patients with Acute Pancreatitis. J Immunol. 2019 May 1;202(9):2578-2584

17    Lu P, Geng J , Zhang L, Wang Y, Niu NN, Fang Y, Liu F, Shi J, Zhang ZG, Sun YW, Wang LW*, Tang YJ*, Xue J*.  THZ1 reveals CDK7-dependent transcriptional addictions in pancreatic cancer. Oncogene. 2019 May;38(20):3932-3945.

18    He WZ, Wu JH, Shi JJ, Huo YM, Dai WT, Geng J, Lu P, Yang MW, Fang Y, Wang W, Zhang ZG, Habtezion A*,Sun YW*, Xue J*. IL-22RA1/ STAT3 signaling promotes stemness and tumorigenicity in pancreatic cancer. Cancer Research, 2018 Jun 15;78(12):3293-3305

19    Wu JH, Zhang RL, Hu GY, Zhu, HH, Gao WQ, Xue J*. Carbon Monoxide Impairs CD11b+Ly-6Chi Monocyte Migration from the Blood to Inflamed Pancreas via Inhibition of the CCL2/CCR2 Axis. J Immunol, 2018.3, 200(6): 2104~2114

20    Xue J#, Zhao QL, Sharma V, Nguyen LP, Lee YN, Pham KL, Edderkaoui M, Pandol SJ, Park W, Habtezion A*. Aryl Hydrocarbon Receptor Ligands in Cigarette Smoke Induce Production of Interleukin-22 to Promote Pancreatic Fibrosis in Models of Chronic Pancreatitis. Gastroenterology, 2016,151(6):1206~1217 (* co-corresponding author)

所获项目

1.   国家自然科学基金委优青项目 （主持） 2021/01- 2023/12

2.   国家自然科学基金委面上项目 （主持） 2024/01- 2027.12

3.   国家自然科学基金委面上项目 （主持） 2020/01- 2023/12

4.   国家自然科学基金委面上项目 （主持） 2018/01- 2022/12

5.   国家自然科学基金委青年项目 （主持） 2018/01- 2021/12

6.   上海中组部青年拔尖人才项目 （主持） 2018

7.   上海交通大学高峰高原计划-“临床专职科研队伍”  （主持） 2016，2019

8.   上海高校特聘教授（东方学者） 2015/06-2018/05