微纳米技术与生物医学研究组

刘培峰，博士，研究员，博导，国家“万人计划”青年拔尖人才

研究方向

微纳米技术与疾病诊治

功能材料的生物应用

团队成员

代表性论文

1.    Nachuan Song, Xiaoting Fan, Xiaocui Guo, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Chi Yao*, Peifeng Liu*. A DNA/upconversion nanoparticle complex enables controlled co-delivery of CRISPER-Cas9 and photodynamic agents for synergistic cancer therapy. Advanced Materials. 2024, 2309534.

2.    Zhaoyue Lv, Mengxue Huang, Jing Yang, Peiran Li, Lele Chang, Qianyun Tang, Xiaojing Chen, Shengqi Wang*, Chi Yao*, Peifeng Liu*, Dayong Yang*. A smart DNA-based nanosystem containing ribosome-regulating siRNA for enhanced mRNA transfection. Advanced Materials, 2023, 2300823.

3.    Yuexia Xie, Huishan Li, Lei Xu, Hanbing Zou, Xingang Wang, Xiaozhen He,  Qianyun Tang, Yan Zhou, Xue Zhao, Xiaojing Chen, Hongmei Liu, Jun Pu, Dan Luo, Peifeng Liu*. DNA nanoclusters combined with one‐shot radiotherapy augment cancer immunotherapy efficiency. Advanced Materials, 2023, 35, 2208546.

4.    Xiaojing Chen#, Qianyun Tang#, Jinqiang Wang, Yan Zhou, Fengqin Li, Yuexia Xie, Xingang Wang, Ling Du, Junru Li, Jun Pu, Quanyin Hu, Zhen Gu, Peifeng Liu*. A DNA/DMXAA/metal‐organic framework activator of innate immunity for boosting anticancer immunity. Advanced Materials, 2023, 35, 2210440.

5.    Hongmei Liu, Chongyi Liu, Li Ye, Ding Ma, Xiaozhen He, Qianyun Tang, Xue Zhao, Hanbing Zou, Xiaojing Chen, Peifeng Liu*. Nanoassemblies with effective serum tolerance capability achieving robust gene silencing efficacy for breast cancer gene therapy. Advanced Materials, 2020,33, 2003523.

6.    Nachuan Song, Yiwen Chu, Shuai Li, Xiaoting Fan, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Peifeng Liu*. A dual-enzyme-responsive DNA-based nanoframework enables controlled co-delivery of CRISPER-Cas9 and antisense oligodeoxynucleotide for synergistic gene therapy. Advanced Functional Materials, 2023, 2306634.

7.    Zhaoyue Lv, Zhemian Li, Shaolan Zou, Peiran Li, Nachuan Song, Rui Zhang, Mengdi Xu, Mingxing Liu, Fengqin Li, Junru Li, Peifeng Liu*, Chi Yao*, Dayong Yang*. A smart DNA nanoassembly containing multivalent aptamers enables controlled delivery of crisper/cas9 for cancer immunotherapy. Advanced Functional Materials, 2023, 2311069.

8.    Fengqin Li#, Junru Li#, Weiqiang Yang#, Shuai Yang, Congshuo Chen, Ling Du, Junyang Mei, Qianyun Tang, Xiaojing Chen, Chi Yao, Dayong Yang*, Xiaolei Zuo*, Peifeng Liu*. Framework-hotspot enhanced trans cleavage of CRISPER-Cas12a for clinical samples detection. Angewandte Chemie International Edition, 2023, e202305536.

9.    Dong Wang, Peifeng Liu*, Dan Luo*. Putting DNA to work as generic polymeric materials. Angewandte Chemie International Edition, 2021, 61:2-16.

10.    Chi Yao#, Jianpu Tang#, Chenxu Zhu, Sen Yang, Han Tang, Luxi Dong, Chunzhi Zhang, Qianyun Tang, Peifeng Liu*, Dayong Yang*. A signal processor made from DNA assembly and upconversion nanoparticles for pharmacokinetic study. Nano Today, 2021,42:101352 (IF=17.4)

11.    Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han*, Mingzhe Gan*, Peifeng Liu*. Microfluidic-based spationtemporal control of oxygen concentration in bacteria suspension culture from bulk to the single cells. Nano Today, 2024, 54, 102067.

12.    Yuexia Xie, Jiana Jiang, Qianyun Tang, Hanbing Zou, Xue Zhao, Hongmei Liu, Ding Ma, Chenlei Cai, Yan Zhou, Xiaojing Chen, Jun Pu, Peifeng Liu*. Iron oxide nanoparticles as autophagy intervention agents suppress hepatoma growth by enhancing tumoricidal autophagy. Advanced Science, 2020,7(16):1903323.

13.    Yan Zhou#, Fuwei Gan#, Yuanliang Zhang, Xiaozhen He, Chengshuo Shen, Huibin Qiu*, Peifeng Liu*. Selective killing of cancer cells by nonplanar aromatic hydrocarbon-induced DNA damage. Advanced Science, 2019, 6(21), 1901341.

科研项目

1.    国家自然科学基金面上项目， 2024/01-2027/12，在研，主持

2.    国家自然科学基金面上项目， 2018/01-2021/12，已结题，主持

3.    国家自然科学基金面上项目， 2015/01-2018/12，已结题，主持

4.    国家自然科学基金青年项目， 2012/01-2014/12，已结题，主持

5.    上海市科委科技创新项目， 2023/01-2025/12，在研，主持

6.    上海市卫健委新兴交叉项目，2023/01-2025/12，在研，主持

7.    上海交通大学转化医学交叉研究基金-重点项目，2019/1-2021/12，在研，主持

获得专利

1.    一种肿瘤微环境响应型基因纳米胶束及其制备方法和应用，发明专利

2.    一种ATP响应型纳米胶束、制备方法和应用，发明专利

3.     一种肿瘤微环境响应型基因纳米胶束及其制备方法和应用，发明专利

4.     一种基于CRISPER技术与框架核酸耦合的模块化检测平台、构建方法及其应用，发明专利