课题组长

刘永忠博士，研究员，博士生导师

研究方向

肿瘤细胞和免疫系统相互作用所形成的免疫微环境格局影响肿瘤的发生和发展； 肿瘤细胞内异常的分子信号通路是肿瘤免疫微环境组成和格局的主控因素, 而免疫系统的编辑作用也可促进肿瘤细胞的适应性和恶性演进。研究肿瘤细胞和免疫系统相互作用的分子机制不仅有助于认识肿瘤进展的机制，也将为肿瘤治疗提供新策略。目前，本研究组主要方向：肿瘤免疫逃逸机制及干预。

研究组成员

工作人员 ： 杨兆娟，刘昀，张力，许桂琴，相绿竹

研究生 ：   许晨，左佑，郑宁倩，叶志谦，张忆宁

代表性论文

1.    Liu Y, Xu C, Zhang L, Xu G, Yang Z, Xiang L, Jiao K, Chen Z, Zhang X, Liu Y. Syndecan-1 inhibition promotes antitumor immune response and facilitates the efficacy of anti-PD1 checkpoint immunotherapy. Sci Adv. Sep 13;10(37):eadi7764(2024).

2.    Zhang L, Jiao K, Liu Y, Xu G, Yang Z, Xiang L, Chen Z, Xu C, Zuo Y, Wu Z, Zheng N, Zhang X, Xia Q, Liu Y. UBXN9 inhibits the RNA exosome function to promote T cell control of liver tumorigenesis. Hepatology. 80(5):1041–1057 (2024)

3.    Yang Z, Xu G, Wang B, Liu Y, Zhang L, Jing T, Tang M, Xu X, Jiao K, Xiang L, Fu Y, Tang D, Zhang X, Jin W, Zhuang G, Zhao X, Liu Y. USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. Nat Commun. 11;12(1):4852. (2021)

4.    Xu G, Yang Z, Ding Y, Liu Y, Zhang L, Wang B, Tang M, Jing T, Jiao K, Xu X, Chen Z, Xiang L, Xu C, Fu Y, Zhao X, Jin W, Liu Y. The deubiquitinase USP16 functions as an oncogenic factor in K-RAS-driven lung tumorigenesis. Oncogene. 40(36):5482-5494 (2021).

5.    Liu Y, Zhang L, Wang B, Yang Z, Xu G, Ma A, Tang M, Jing T, Wu L, Xu X, Liu Y. Requirement for POH1 in differentiation and maintenance of regulatory T cells. Cell Death Differ. 26, 751-762(2019).

6.    Ma A, Tang M, Zhang L, Wang B, Yang Z, Liu Y, Xu G, Wu L, Jing T, Xu X, Yang S, Liu Y. USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis. Oncogene. 38, 2405-2419(2019).

7.    Zhang L, Liu Y, Wang B, Xu G, Yang Z, Tang M, Ma A, Jing T, Xu X, Zhang X, Liu Y. POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity. Nat Commun. 1, 4225 (2018).

8.    Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y. POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Nat Commun. 6, 8704（2015）.

9.    Zhang L, Yang Z, Ma A, Qu Y, Xia S, Xu D, Ge C, Qiu B, Xia Q, Li J, Liu Y.  Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma. Hepatology. 59,178-89 (2014).

10.    Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, Chen W. A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells.  Nat Immunol. Jun;9(6):632-40(2008).

科研项目

1.    国家自然基金面上项目（82273002，81972579，81572293，30972686）

2.    国自然重大项目培育基金（91129715）

3.    国家科技重大专项子课题（2013ZX10002011-002）