1997年获日本国立山口大学博士学位，现任上海市肿瘤研究所癌基因及相关基因国家重点实验室研究团队负责人。已承担国家自然科学基金面上项目5项、“十一五”、“十二五”国家科技重大专项课题各1项、“十三五”国家科技重大专项子课题1项，参加973项目1项，目前承担在研国家自然科学基金面上项目2项、。2011至2020年期间，发表SCI论文71篇（其中通讯作者33篇，包括2篇Hepatology、1篇Biomaterials、3篇Cancer Res、1篇Mol Cancer Therap杂志文章），参编专著2部。申报国家发明专利14项（其中11项已授权）。2006年享受国务院特殊津贴，2009年入选市优秀学科带头人培养计划（A类）、上海领军人才“地方”培养计划，“新世纪百千万人才工程”国家级人才培养计划。第十二届、十三届上海市政协委员。

1．肝癌干细胞的靶向治疗临床基础研究

2．肝癌耐药分子机制研究

3．肿瘤转移分子机制研究

1.      Xiaoxia Chen, Tianshu Chen, Lili Zhang, Zhenyu Wang, Qingqing Zhou, Tingting Huang, Chao Ge, Huili Xu, Miaoxin Zhu, Fangyu Zhao, Ming Yao, Hua Tian, Hong Li, Xiaoli Zhu#, Jinjun Li#. Cyclodextrin-Mediated Formation of Porous RNA Nanospheres and Their Application in Synergistic Targeted Therapeutics of Hepatocellular Carcinoma. Biomaterials 261:120304, 2020 

2.      Zhang L*, Huo Q*, Ge C, Zhao F, Zhou Q, Chen X, Tian H, Chen T, Xie H, Cui Y, Yao M, Li H#, Li J#. ZNF143-mediated H3K9 trimethylation upregulates CDC6 by activating MDIG in hepatocellular carcinoma. Cancer Res 80(12): 2599-611, 2020    

3.      Jing Yang*, Lili Zhang*, Zhiyuan Jiang, Chao Ge, Fangyu Zhao, Jingyi Jiang, Hua Tian, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Hong Li, Jinjun Li#. TCF12 promotes the tumorigenesis and metastasis of hepatocellular carcinoma via upregulation of CXCR4 expression. Theranostics 9(20): 5810-5827, 2019 

4.      Cong Chen, Chao Ge, Zheng Liu, Liangyu Li, Fangyu Zhao, Hua Tian, Taoyang Chen, Hong Li, Ming Yao, Jinjun Li#. ATF3 inhibits the tumorigenesis and progression of hepatocellular carcinoma cells via upregulation of CYR61 expression. J Exp Clin Cancer Res 37(1):263, 2018  

5.      Jiang J*, Liu Z*, Ge C, Chen C, Zhao F, Li H, Chen T, Yao M, Li J#. NK3 Homeobox 1 (NKX3.1) Upregulates Forkhead Box O1 Expression in Hepatocellular Carcinoma and Thereby Suppresses Tumor Proliferation and Invasion. J Biol Chem 292(47) 19146–19159, 2017

6.      Huo Q, Ge C, Tian H, Sun J, Cui M, Li H, Zhao F, Chen T, Xie H, Cui Y, Yao M, Li J#. Dysfunction of IKZF1/MYC/MDIG axis contributes to liver cancer progression through regulating H3K9me3/p21 activity. Cell Death Dis. 8(5):e2766, 2017

7.      Hua Tian, Chao Ge, Fangyu Zhao, Miaoxin Zhu, Lin Zhang, Qi Huo, Hong Li, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li#. Downregulation of AZGP1 by Ikaros and histone deacetylase promotes metastasis through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma. Carcinogenesis 38 (2): 207-217, 2017

8.      Zhang L, Ge C, Zhao F, Zhang Y, Wang X, Yao M, Li J#. NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling. Cancer Res 76(23): 7059-71, 2016

9.      Hua Tian, Chao Ge, Hong Li, Fangyu Zhao, Helei Hou, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li#. Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma. Hepatology 59(4): 1459-1470, 2014

10.   Helei Hou, Hefen Sun, Ping Lu, Chao Ge, Lixing Zhang, Hong Li, Fangyu Zhao, Hua Tian, Lin Zhang, Taoyang Chen, Ming Yao, Jinjun Li#. Tunicamycin potentiates cisplatin anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse xenograft models of human hepatocellular carcinoma. Mol Cancer Therap  12(12): 2874-2884, 2013

11.   Lixing Zhang, Hefen Sun, Fangyu Zhao, Ping Lu, Chao Ge, Hong Li, Helei Hou, Mingxia Yan, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Xiaowu Huang, Jia Fan, Ming Yao, Jinjun Li#. BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocelluar carcinoma. Cancer Res 72(16): 4276-4285, 2012

12.   Hong Li, Chao Ge, Fangyu Zhao, Mingxia Yan, Chen Hu, Deshui Jia, Hua Tian, Miaoxin Zhu,Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Jianren Gu, Hong Tu, Xianghuo He, Ming Yao, Yongzhong Liu, Jinjun Li#. HIF-1α-activated ANGPTL4 contributes to tumor metastasis via VCAM-1/integrin β1 signaling in human hepatocellular carcinoma. Hepatology 54(3): 910-919, 2011

13.   Zheng Zhu*, Xiangfang Hao*, Mingxia Yan, Ming Yao, Chao Ge, Jianren Gu, Jinjun Li#. Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma. Int J Cancer 126(9): 2067-2078, 2010

14.   Chen Hu*, Hong Li*, Jin-Jun Li#, Zheng Zhu, Sheng-Yong Yin, Xiang-Fang Hao, Ming Yao, Shu-Sen Zheng, Jian-Ren Gu. Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling. Carcinogenesis, 29(12): 2289-2297, 2008.

15.   Yin S*, Li J*, Hu C, Chen X, Yao M, Yan M, Jiang G, Ge C, Xie H, Wan D, Yang S, Zheng S#, Gu J#. CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer  120(7):1444-1450, 2007  

1. 国家自然科学基金面上项目“ZNF143/MDIG/CDC6信号通路在肝癌发生发展中的作用和机制研究”（81972580）2020.1-2023.12,55万元，主持。

2. 国家自然科学基金面上项目“IKZF1/CD133/MINA53信号通路在维持肝癌干细胞干性中的作用和机制研究”（81773152）2018.1-2021.12，55万元，主持。

3. 国家自然科学基金面上项目“转录因子Ikaros在抑制肝癌干细胞增殖中的功能和分子机制研究”（81472726）2015.1-2018.12，72万元，主持。

4. 国家自然科学基金面上项目“天然生物碱ISO-X/ICD 选择性杀伤肝癌干细胞作用及机制研究”（81272438）2013.1-2016.12，70万元，主持。

5. 国家科技重大专项课题“解决肝癌耐药的新策略研究”（2013ZX10002011）2013.1-2015.12，500万元，主持。

6. 国家自然科学基金委及香港研究资助局联合研究计划“人肝细胞癌Wnt/beta-catenin信号传导调控分子的研究”（30731160004）2007.1-2009.12，35万元，主持。

工作人员：

      赵新阁  博士  助理研究员

      葛  超  本科  主管技师

研究生：

      陈晓霞 博士生

      王振宇 博士生

      周涟儿 硕士生