卜军教授，上海交通大学医学院附属仁济医院心内科（国家临床重点专科、国家教育部211重点学科）学科带头人、行政主任、主任医师、博导，国家重点实验室/上海市肿瘤研究所“肿瘤与代谢及炎症性疾病组”PI，教育部长江学者特聘教授、国家杰出青年基金获得者、国家万人计划领军人才、科技部中青年领军人才、国家重点研发计划首席科学家、美国心脏病学会专家会员(FACC)、欧洲心脏病学会专家会员(FESC)、亚太心脏病学会理事。主要研究方向为：1. 心血管病及肿瘤发病机制与干预；2. 慢病大队列与单细胞及多组学研究。系列原创性成果发表在国际重要期刊，总影响因子超过1000分，写入国际内科学教科书和欧洲影像学指南等行业规范，是TCT、CRT、EuroPCR等国际心血管大会的国际主席团成员，先后获“教育部新世纪优秀人才”、“吴孟超医学青年奖”、“树兰医学青年奖”等。

肿瘤与代谢及炎症性疾病

代表性SCI论著33篇（IF>5，均为一作或通讯作者*，按照2020最新IF排列）

1. Shi JF, Tong RY, Zhou M, Gao Y, Zhao YC, Chen YF, Liu WH, Li GX, Lu D, Meng GF, Yuan AC, Hu LH, Pu J*. Circadian nuclear receptor Rev-erbα is expressed by platelets and regulates platelet activation and thrombus formation. Eur Heart J. 2022. (Accepted). IF=29.983

2. Pu J, Yuan A, Shan P, Gao E, Wang X, Wang Y, Lau W, Ma XL, He B. Cardiomyocyte Expressed Farnesoid-X-Receptor is a Novel Apoptosis Mediator and Contributes to Myocardial Ischemia/Reperfusion Injury. Eur Heart J.2013.34:1834-45. IF=29.983

3. Pu J, Mintz GS, Brilakis ES, Banerjee S, Abdel-Karim AR, Maini B, Biro S, Lee JB, Stone GW, Weisz G, Maehara A. In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy. Eur Heart J.2012.33:372-83. IF=29.983

4. Pu J, Ding S, Ge H, Han Y, Lin R, Guo J, Lin R, Su X, Zhang H, Chen L, He B. EARLY-MYO Investigators (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment-Elevation Myocardial Infarction). Circulation.2017.136(16):1462-1473. IF=29.69

5. Pu J, Mintz GS, Biro S, Lee JB, Stone GW, Weisz G, Maehara A. Insights into echo-attenuated plaques, echolucent plaques, and plaques with spotty calcification: novel findings from comparisons among intravascular ultrasound, near-infrared spectroscopy, and pathological histology in 2,294 human coronary artery segments.J Am Coll Cardiol.2014.63(21):2220-33. IF=24.094

6. Zhao YC#, Gao LC#, Jiang CL, Chen JQ, Qin ZH, Zhong FY, Yang Y, Tong RY, Zhou M, Yuan AC, Pu J*. The transcription factor ZHX2 alleviates nonalcoholic steatohepatitis by transcriptional activation of PTEN.Hepatology.2021.1866(11):165890. IF=17.425

7. Zhao Y#, Wang F#, Gao L#, Xu L, Tong R, Lin N, Su Y, Yan Y, Gao Y, He J, Kong L, Yuan A, Zhuge Y, Pu J*. Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease. Hepatology.2018.68(3):897-917. IF=17.425

8. Song H#, Pu J#, Wang L, Wu L, Xiao J, Liu Q, Chen J, Zhang M, Liu Y, Ni M, Mo J, Zheng Y, Wan D, Cai X, Cao Y, Xiao W, Ye L, Tu E, Lin Z, Wen J, Lu X, He J, Peng Y, Su J, Zhang H, Zhao Y*, Lin M*, Zhang Z*. ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation. Autophagy. 2015;11(8):1308-25. (IF=16.016)

9. Deng KQ, Wang A, Ji YX, Zhang XJ, Fang J, Zhang Y, Zhang P, Jiang X, Gao L, Zhu XY, Zhao Y, Gao L, Yang Q, Zhu XH, Wei X, Pu J*, Li H*. Suppressor of IKKε is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun.2016.7:11432. IF=14.919

10. Xu L#, Su Y#, Zhao Y#, Sheng X, Tong R, Ying X, Gao L, Ji Q, Gao Y, Yan Y, Yuan A, Wu F, Lan F, Pu J*. Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling. J Pineal Res.2019.67(2): e12579. IF=13.007

11. Ding S#, Lin N#, Sheng X#, Zhao Y, Su Y, Xu L, Tong R, Yan Y, Fu Y, He J, Gao Y, Yuan A, Ye L, Reiter RJ, Pu J*. Melatonin stabilizes rupture-prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORα-dependent manner. J Pineal Res.2019.67(2): e12581. IF=13.007

12. Zhao Y#, Xu L#, Ding S#, Lin N, Ji Q, Gao L, Su Y, He B*, Pu J*. Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy. J Pineal Res.2017.62(3). IF=13.007

13. He B, Zhao Y, Xu L, Gao L, Su Y, Lin N, Pu J*. The Nuclear Melatonin Receptor RORα Is a Novel Endogenous Defender Against Myocardial Ischemia/Reperfusion Injury. J Pineal Res.2016.60(3):313-26. IF=13.007

14. Jiang P#, Feng ZH#, Sheng L#, Hu CX, Ma X, Zhang SY, Wu, LM, Xiao X, Wang QX, Guo CJ, Qiu DK; Fang JY, Xu JR, Gershwin Merrill Eric, Jiang M*, Ma X*, Pu J*. Morphological, Functional and Tissue Characterization of Silent Myocardial Involvement in Patients with Primary Biliary Cholangitis. Clin Gastroenterol Hepatol. 2021.S1542-3565(21):00915. IF=11.382

15. Gu ZC#, Wei AH#, Zhang C#, Wang XH, Zhang L, Shen L, Li Z, Pan MM, Liu XY, Pu J*, Lin HW*. Risk of Major Gastrointestinal Bleeding with New vs Conventional Oral Anticoagulants: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2020.18(4):792-799. IF=11.382

16. Leng S#, Ge H#, He J, Kong L, Yang Y, Yan F, Xiu J, Shan P, Zhao S, Tan RS, Zhao X, Koh AS, Allen JC, Hausenloy DJ, Mintz GS, Zhong L, Pu J*. Long-term Prognostic Value of Cardiac MRI Left Atrial Strain in ST-Segment Elevation Myocardial Infarction. Radiology.2020.296(2):299-309. IF=11.105

17. Guo Q, Wu LM, Wang Z, Shen JY, Su X, Wang CQ, Gong XR, Yan QR, He Q, Zhang W, Xu JR*, Jiang M*, Pu J*. Early Detection of Silent Myocardial Impairment in Patients with New Onset Drug-Naïve Systemic Lupus Erythematosus -- A Three-Center Prospective Study. Arthritis & Rheumatology.2018.70(12):2014-2024. IF=10.995

18. Ying X#, Zhao Y#, Yao T, Yuan A, Xu L, Gao L, Ding S, Ding H, Pu J*, He B*. Novel Protective Role for Ubiquitin-Specific Protease 18 in Pathological Cardiac Remodeling. Hypertension. 2016.68(5):1160-70. IF=10.19

19. He B, Zhao YC, Gao LC, Ying XY, Xu LW, Su YY, Ji QQ, Lin N, Pu J *. Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Pathological Cardiac Hypertrophy. Hypertension. 2016.67(6):1237-48. IF=10.19

20. Sun B#, Li X#, Liu X#*, Ge X, Lu Q, Zhao X, Pu J*, Xu J, Zhao H*. Association between carotid plaque characteristics and acute cerebral infarction determined by MRI in patients with type 2 diabetes mellitus. Cardiovasc Diabetol.2017.16(1):111. IF=9.951

21. He Q, Pu J*, Yuan A, Yao T, Ying X, Zhao Y, Xu L, Tong H, He B. Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice. Cardiovasc Diabetol. 2014;13(1): 149. (IF=9.951)

22. He Q, Pu J*, Yuan A, Lau WB, Gao E, Koch WJ, Ma XL*, He B*. Activation of liver-X-receptor α but not liver-X-receptor β protects against myocardial ischemia/reperfusion injury. Circ Heart Fail. 2014;7(6): 1032-41. (IF=8.846)

23. Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, Ding S, Liu J, Peng X, Gao E, Pu J*, He B*. Vitamin d Receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy. Antioxid Redox Signal. 2015; 22(8): 633-50. (IF=8.401)

24. Luo G#, Qian Y#, Sheng X, Sun J, Wu Z, Liao F, Feng Q, Yin Y, Ding S*, Pu J*. Elevated Serum Levels of Soluble ST2 Are Associated with Plaque Vulnerability in Patients with Non-ST-Elevation Acute Coronary Syndrome. Front Cardiovasc Med.2021 Jul 22; 8:688522. IF=6.05

25. Wei L#, He J#, Dong J#, Kong L, Zeng J, Shi B, An D, Chen B, Ding S, Li Z, Yang F, Yang Y, Yan F, Xiu J, Wang H, Xu J, Ge H*, Pu J*. Impact of Concomitant Impairments of the Left and Right Ventricular Myocardial Strain on the Prognoses of Patients With ST-Elevation Myocardial Infarction. Front Cardiovasc Med. 2021 May 31;8:659364. IF=6.05

26. Sun JT#, Chen Z#, Nie P#, Ge H, Shen L, Yang F, Qu XL, Ying XY, Zhou Y, Wang W, Zhang M, Pu J*. Lipid Profile Features and Their Associations with Disease Severity and Mortality in Patients With COVID-19. Front Cardiovasc Med.2020.7:584987. IF=6.05

27. Chen YF, Pu J*. Understanding the Clinical Features of Coronavirus Disease 2019 from the Perspective of Aging: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne).2020.11:557333. IF=5.555

28. Bu Z#, Ma J#, Fan Y#, Qiao Z, Kang Y, Zheng Y, Wang W, Du Y, Zheng Z, Shen X, He B*, Pu J*. Ascending Aortic Strain Analysis Using 2-Dimensional Speckle Tracking Echocardiography Improves the Diagnostics for Coronary Artery Stenosis in Patients with Suspected Stable Angina Pectoris. J Am Heart Assoc.2018.7(14): e008802. IF=5.501

29. Wei A#, Gu Z#, Li J, Liu X, Wu X, Han Y*, Pu J*. Clinical Adverse Effects of Endothelin Receptor Antagonists: Insights from the Meta-Analysis of 4894 Patients From 24 Randomized Double-Blind Placebo-Controlled Clinical Trials. J Am Heart Assoc.2016.5(11): IF=5.501

30. Chen BH#, An DA#, He J, Wu CW, Yue T, Wu R, Shi RY, Eteer K, Joseph B, Hu J, Xu JR*, Wu LM*, Pu J*. Myocardial extracellular volume fraction radiomics analysis for differentiation of reversible versus irreversible myocardial damage and prediction of left ventricular adverse remodeling after ST-elevation myocardial infarction. Eur Radiol.2021.31(1):504-514. IF=5.315

31. Xiao QQ, Che XY, Cai B, Tao ZY, Zhang HY, Shao Q*, Pu J*. Macrophage autophagy regulates mitochondria-mediated apoptosis and inhibits necrotic core formation in vulnerable plaques. J Cell Mol Med.2020.24(1):260-275. IF=5.319

32. Zang M#, Zhao Y#, Gao L#, Zhong F, Qin Z, Tong R, Ai L, Petersen L, Yan Y, Gao Y, Zhu C*, Pu J*. The circadian nuclear receptor RORα negatively regulates cerebral ischemia-reperfusion injury and mediates the neuroprotective effects of melatonin. Biochim Biophys Acta Mol Basis Dis.2020.1866(11):165890. IF=5.187

33. Chen YF, Yang F, Pu J*. Visualization of cardiovascular development, physiology and disease at the single-cell level: Opportunities and future challenges. J Mol Cell Cardiol.2020.142:80-92. IF=5.000

1.        国家自然科学基金重点项目，编号81930007、“昼夜节律对梗死后心肌修复和重构的影响：生物钟核受体RORα信号通路的关键作用”、2020/01/01-2024/12/31、297万元、在研、主持。

2.        宁波市卫生计生委甬江引才工程，“基于大队列的心脑血管重大疾病多维度组学平台的建立与应用”、 2021/9/1 -2026/8/31、500万元、在研、主持。

3.        上海市科委科技创新行动计划实验动物研究领域项目，编号 201409005200、“模拟人类熬夜/夜班工作的大动物心脏疾病模型建立及与传统小动物模型的比较研究”、2020/06/30-2023/06/30、20万元、在研、主持。

4.        上海市浦东新区卫生健康委员会联合攻关项目，编号PW2019D-11、“浦东队列心脑血管慢病‘协防共管‘创新模式的开发和应用”、2019/11/01-2022/10/31、30万元、在研、主持。

5.        上海市肿瘤研究所自主课题，编号ZZ-20-22SYL、”基于队列样本研究癌症患者发病前后免疫细胞功能特点及早期诊断标记物“、2020/07/01-2023/06/30、50万元、在研、主持。

6.        国家重点研发专项，编号2018YFC1312800、“心脑血管疾病`协防共管’创新健康管理模式的开发与效果评价”、2018/09-2021/12、1534万元、已结题、项目总负责人及首席科学家。

7.        国家杰出青年基金，编号81625002、“心血管内科学 (冠心病事件链机制及干预)”、2017/01-2021/12、350万元、已结题、主持。

8.        上海交通大学医学院多中心临床研究项目，编号DLY201804、“早期使用重组人脑利钠肽对急性心肌梗死患者心肌组织水平灌注及心室重构的影响：前瞻性、随机开放、平行对照、多中心临床试验”、2019/01/01-2020/12/31、50万元、已结题、主持。

9.        上海市科委优秀学术带头人计划，编号18XD1402400、“生物钟核受体NR1F1在急性心梗心肌组织水平灌注不良中的关键保护作用”、2018/05-2021/4、40万元、已结题、主持。

10.    上海市申康临床创新行动计划项目，编号16CR3034A、“基于三维定量心肌微循环功能的血流储备评估新技术的建立与应用”、2016/12-2019/06、50万元、已结题、主持。

11.    上海市教委高峰高原人才项目，编号20152209、“以TMPFC为核心的新型急性心肌死心肌组织水平再灌注临床技术的建立与优化应用”、2015/01-2017/12、100万元、已结题、主持。

12.    国家自然科学基金面上项目，编号81470389、“核受体FXR-SHP级联通路参与心肌细胞肥大与心肌成纤维细胞增殖的双重调控及其分子机制”、2015/01- 2018/12、75万元、已结题、主持。

13.    上海市科委基础研究重点项目，编号14JC1404500 、“肝X受体不同亚型在急性心肌梗死及其后续心肌重构与功能重建中的靶点作用及其关键调控机制”、2014/01-2016/12、50万元、已结题、主持。

14.    国家自然科学基金面上项目，编号81270282、“FXR受体通过线粒体途径诱导心肌缺血再灌注损伤的新机制：孤儿受体SHP的关键作用”、2013/01-2016/12、70万元、已结题、主持。

15.    国家教育部新世纪优秀人才计划，编号 NCET-12-0352、“RAR相关孤儿受体在动脉粥样硬化斑块稳定性中的作用及其机制 ”、2013/01-2015/12 、50万元、已结题、主持。

16.    上海市曙光计划人才项目，编号12SG-22、“视黄酸相关受体ROR：调控动脉粥样硬化斑块稳定性的新靶点”、2013/01-2015/12、15万元、已结题、主持。

17.    上海市科委国际合作课题，编号12410708300、“急性心肌梗死心肌组织水平灌注的新型评估技术体系建立与优化应用”、2012/01¬-2014/12、25万元、已结题、主持。

18.    国家自然科学基金面上项目，编号81070176、“缺血心肌再灌注及梗死后重塑过程中视黄醛X受体与NR4A1孤核受体通路在线粒体水平的交叉对话及机制”、2011/01-2013/12、32万元、已结题、主持。

19.    上海市教委高校选拔优青专项基金，编号:JDY06034，“RXR核受体：新的抗心力衰竭的药物靶点”、2007/1-2009/12、10万元、已结题、主持。

20.    国家自然科学基金青年基金，编号30600242、“独特的RXR受体 /Nur77受体信号通路参与心肌肥厚和凋亡的双重调控的分子机制研究”、2007/01-2009/12，23万元、已结题、主持。