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任职经历： 研究经历： 组长：徐宇虹，教授
课题组成员
研究方向 专利： 1. 顾健人、李宗海、徐宇红、吴向华. 人表皮生长因子受体EGFR的配体多肽及其DNA序列. 专利号：ZL200410017334.6 2. 顾健人、吴向华、徐宇红、李宗海.Tie2受体介导的靶向性肿瘤基因治疗的基因转移系统. 专利号:ZL200310122830.3 3. 李宗海、顾健人、杨胜利、张捷、石必枝. 一种制备展示多肽的噬菌粒颗粒的方法. 专利申请号：200610027943.9 4. 李宗海、顾健人、蒋华、徐宇虹. 表皮生长因子与绿色荧光蛋白的融合蛋白.专利申请号：200610028346.8 5. 李宗海、顾健人、杨胜利、石必枝、王华茂、蒋华. Hpd3cell、制备方法及其用于构建丝状噬菌体单链抗体库的用途.专利申请号：200710041416.8 近期论文： 1. Zonghai Li, Ruijiao Zhao, Xianghua Wu, Ye Sun, Ming Yao, Jinjun Li, Yuhong Xu*, Jianren Gu*. Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics. FASEB J; 2005;19（14）：1978-1985 , 2. Zonghai Li，Jie Zhang，Ruijiao Zhao，Yuhong Xu* and Jianren Gu*. Preparation of peptide-targeted phagemid particles using protein III modified helper phage. BioTechniques. 2005;39(4): 493-496. 3. Liang, Y., Shi, B., Zhang, J., Jiang, H., Xu, Y., Li, Z*. and Gu, J*. Better Gene Expression by (-)Gene than by (+)Gene in phage gene delivery systems. Biotechnology Progress. 2006 May-Jun;22(3):626-30. 4. *Zonghai Li*, Hua Jiang, Jie Zhang, *Jianren Gu，Cell targeted phagemid particles preparation using E.coli bearing ligand-pIII encoding helper phage genome，BioTechniques, 2006，41（6）：706-707. 5. Hua Jiang, Jie Zhang, Bizhi Shi, Yuhong Xu, Zonghai Li*, Jianren Gu *， Application of EGFP-EGF Fusions to Explore the Mechanism of Endocytosis of Epidermal Growth Factor Receptor， Acta Pharmacol Sin. 2007 Jan;28(1):111-7 6. Bizhi Shi, Huamao Wang, Shengrong Guo, Yuhong Xu, Zonghai Li*, Jianren Gu*， Protein III-based single-chain antibody phage display using bacterial cells bearing an additional genome of a gene-III-lacking helper phage. BioTechniques, 2007：42（6）756-9 7. Jiang Hua, Xiumei Cai, Bizhi Shi,Jie Zhang, Zonghai Li*, Jianren Gu，Development of efficient RNA interference system using EGF-displaying phagemid particles. Acta Pharmacol Sin. 2008, In press. 8. Wu X, Zhao R, Li Zonghai, Ming Yao, Huamao Wang, Junsong Han, Shumin Qu, Xianlian Chen, Lianfang Qian, Ye Sun, Yuhong Xu, and Jianren Gu*. A novel small peptide as a targeting ligand for receptor tyrosine kinase Tie2. Biochem Biophys Res Co. 2004，315(4):1004-10. 9. Shuiliang Wang, FeLan, Li Huang, Li Dong, Zh Zhu, Zonghai Li , You Xie，Ji Fu. Suppression of hLRH-1 mediated by a DNA vector-based RNA interference results in cell cycle arrest and induction of apoptosis in hepatocellular carcinoma cell BEL-7402. Biochem and Biophy Res Co. 2005, 333: 917-924 10. Yaqiong Zhang, Shengrong Guo*, Chengfei Lu, Li Liu, Zonghai Li, Jianren Gu, Poly (ε-caprolactone)-b-Poly (ethylene glycol)-b-Poly (ε-caprolactone) Triblock Copolymers：Synthesis and Self-Assembly in Aqueous Solutions, Journal of Polymer Science Part A: Polymer Chemistry, 2007，45（4）：605-13. 11. Na Zhang, Shengrong Guo*, Huiqin Li, Li Liu, Zonghai Li, Jianren Gu, Synthesis of Three Types of Amphiphilic Poly(ethylene glycol)-block-Poly(sebacic anhydride) Copolymers and Studies of their Micellar Solutions, Macromolecular Chemistry and Physics, 207(2006) 1359-1367. 12. Chengfei LU, Shengrong GUO*, Li Liu, Yaqiong ZHANG, Zonghai LI, Jianren GU Aggregation Behavior of MPEG-PCL Diblock Copolymers in Aqueous Solutions. Journal of Polymer Science Part B: Polymer Physics, 2006. 44，3406-3417 13. Guo Y，Sun Y，Gu J，Xu Y *. Capillary electrophoresis analysis of poly(ethylene glycol) and ligand-modified polylysine gene delivery vectors. ，Analytical Biochemistry, 2007, 363(2): 204-9 Note: * Corresponding author 编著：参编《抗肿瘤药物研究与开发》 甄永苏 主编，化工出版社，2004 第一版 授课: 复旦大学医学院研究生课程《肿瘤分子生物学》，主讲“肿瘤基因治疗”。 欢迎加盟 竭诚欢迎具有单克隆抗体人源化、蛋白表达纯化及大规模制备、生物制品临床前研究工作经验的人士加盟，待遇面谈。 |
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研究团队
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